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<p>Nasopharyngitis is a common clinical scenario that may often be overlooked. However, it may lead to dire effects if action is not taken during acute setting, especially in immunocompromised patients. Skull base osteomyelitis is a rare complication of bacterial nasopharyngitis and the infection originates from the nose and paranasal sinuses. It is considered an atypical skull-base osteomyelitis as opposed to the typical otogenic causes. We present a rare case of bacterial nasopharyngitis complicated with atypical skull base osteomyelitis in a 69-year-old woman who presented with left sided headache with no apparent nasal or ear symptoms. The serial clinical and radiological characteristics mimic those of a malignant neoplasm of the nasopharynx, posing a diagnostic dilemma and requiring a complex management approach. Long-term antimicrobial therapy for a minimum of 6&#xa0;weeks and addressing uncontrolled comorbidities remain the gold standard. Prompt diagnosis and intervention are crucial to prevent complications and disease progression.</p>

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Simple Bacterial Nasopharyngitis Leading To Atypical Skull Base Osteomyelitis—A Case Report

  • 期刊论文

  • 发表日期：

    2025年8月13日

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  • Piriya Darishini Renganathen,
  • Enci Yong,
  • Azman Ali,
  • R. Komathi S. Ramachandran,
  • Mazlinda Mahadzir,
  • Irise Hoi Khin Chen

摘要

Nasopharyngitis is a common clinical scenario that may often be overlooked. However, it may lead to dire effects if action is not taken during acute setting, especially in immunocompromised patients. Skull base osteomyelitis is a rare complication of bacterial nasopharyngitis and the infection originates from the nose and paranasal sinuses. It is considered an atypical skull-base osteomyelitis as opposed to the typical otogenic causes. We present a rare case of bacterial nasopharyngitis complicated with atypical skull base osteomyelitis in a 69-year-old woman who presented with left sided headache with no apparent nasal or ear symptoms. The serial clinical and radiological characteristics mimic those of a malignant neoplasm of the nasopharynx, posing a diagnostic dilemma and requiring a complex management approach. Long-term antimicrobial therapy for a minimum of 6 weeks and addressing uncontrolled comorbidities remain the gold standard. Prompt diagnosis and intervention are crucial to prevent complications and disease progression.