Scholarlink

Introduction <p>Parotid gland tumours constitute a significant portion of salivary gland neoplasms, with a notable proportion being malignant. Surgical excision remains the primary treatment, but perineural invasion is recognized as a critical adverse prognostic factor. The limited literature on its impact motivates our study to explore its clinical predictors and outcomes.</p> Methodology <p>Our study’s methodology is robust and reliable. It is a retrospective record review that uses electronic medical records to analyze parotid gland cancer cases in patients aged 18 and older. The data is meticulously cleaned in Excel and rigorously analyzed in IBM SPSS 29, ensuring the validity and reliability of our findings.</p> Results <p>Our study involved 20 participants with parotid gland carcinoma, with predominantly male (<i>n</i> = 13, 65%) and a mean age of 48.4 years. Tumor types included mucoepidermoid carcinoma (<i>n</i> = 8, 40%) and metastasis (<i>n</i> = 6, 30%). Most tumours were located in both lobes (<i>n</i> = 13, 65%). Perineural invasion (PNI) was present in 7 cases (35%), with considerable nerve involvement in 2 cases (10%). Treatment included Complete superficial parotidectomy (<i>n</i> = 12, 60%), total parotidectomy (<i>n</i> = 5, 25%), and radical parotidectomy (<i>n</i> = 3, 15%). Radiotherapy (XRT) was administered to 5 participants (25%) but showed poor response. Perineural invasion (PNI) in parotid gland carcinoma was significantly associated with older age (<i>p</i> = 0.006), high-grade tumours (<i>p</i> = 0.015), and advanced N-stage (<i>p</i> = 0.010). PNI was more common in left parotid cases (<i>p</i> = 0.057) and in cases with total or radical parotidectomy (<i>p</i> = 0.005).</p> Conclusion <p>Our findings underscore the significant association of perineural invasion (PNI) in parotid gland carcinoma with older age, high-grade tumours, and advanced N-stage. The prevalence of PNI in left parotid cases and patients undergoing total or radical parotidectomy further highlights its impact on tumour characteristics and treatment outcomes. These findings provide valuable insights for clinical management and treatment planning, emphasizing the need for careful consideration of PNI in treating parotid gland carcinoma.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Perineural Invasion in Parotid Gland Carcinoma as a Determinant of Prognosis and Survival

  • 期刊论文

  • 发表日期：

    2025年9月10日

查看全文
  • Mazin Merdad,
  • Almoaidbellah Rammal,
  • Reem Alzahrani,
  • Hassan Badawoud,
  • Ahmed Aytah,
  • Mohammed Bahabri

摘要

Introduction

Parotid gland tumours constitute a significant portion of salivary gland neoplasms, with a notable proportion being malignant. Surgical excision remains the primary treatment, but perineural invasion is recognized as a critical adverse prognostic factor. The limited literature on its impact motivates our study to explore its clinical predictors and outcomes.

Methodology

Our study’s methodology is robust and reliable. It is a retrospective record review that uses electronic medical records to analyze parotid gland cancer cases in patients aged 18 and older. The data is meticulously cleaned in Excel and rigorously analyzed in IBM SPSS 29, ensuring the validity and reliability of our findings.

Results

Our study involved 20 participants with parotid gland carcinoma, with predominantly male (n = 13, 65%) and a mean age of 48.4 years. Tumor types included mucoepidermoid carcinoma (n = 8, 40%) and metastasis (n = 6, 30%). Most tumours were located in both lobes (n = 13, 65%). Perineural invasion (PNI) was present in 7 cases (35%), with considerable nerve involvement in 2 cases (10%). Treatment included Complete superficial parotidectomy (n = 12, 60%), total parotidectomy (n = 5, 25%), and radical parotidectomy (n = 3, 15%). Radiotherapy (XRT) was administered to 5 participants (25%) but showed poor response. Perineural invasion (PNI) in parotid gland carcinoma was significantly associated with older age (p = 0.006), high-grade tumours (p = 0.015), and advanced N-stage (p = 0.010). PNI was more common in left parotid cases (p = 0.057) and in cases with total or radical parotidectomy (p = 0.005).

Conclusion

Our findings underscore the significant association of perineural invasion (PNI) in parotid gland carcinoma with older age, high-grade tumours, and advanced N-stage. The prevalence of PNI in left parotid cases and patients undergoing total or radical parotidectomy further highlights its impact on tumour characteristics and treatment outcomes. These findings provide valuable insights for clinical management and treatment planning, emphasizing the need for careful consideration of PNI in treating parotid gland carcinoma.