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<p>Aloe Vera (AV), with its anti-inflammatory and antioxidant properties, has been proposed as an alternative therapy for Oral lichen Planus (OLP). This systematic review and meta-analysis aims to evaluate the efficacy of AV in managing OLP symptoms compared to corticosteroids. A systematic review and meta-analysis were conducted following PRISMA guidelines on the Covidence platform. Databases including PubMed, Lilacs, and EBSCO were searched for studies up to April 2024. Inclusion criteria focused on randomized controlled trials (RCTs) comparing AV to corticosteroids in OLP patients. Risk of bias was assessed using the Cochrane Risk-of-Bias tool 2, and the certainty of evidence was evaluated with the GRADE system. Meta-analysis was performed using Review Manager (RevMan) software. Four RCTs involving 226 patients were included. The meta-analysis revealed no statistically significant difference in VAS scores between AV and corticosteroids (<i>n</i> = 226, MD = 0.09, CI -0.17- 0.58, <i>p</i> = 0.50) with considerable heterogeneity (I² = 74%). Similarly, clinical sign scores showed no significant difference (<i>n</i> = 86, MD = -0.26, CI -1.07, 0.54, <i>p</i> = 0.52, I² = 83%). All included studies were assessed to have a high risk of bias. The GRADE assessment indicated very low certainty of evidence for both outcomes. AV demonstrates comparable efficacy to corticosteroids in reducing pain and improving clinical outcomes in OLP, without reported adverse effects. However, significant variability in AV formulations and study methodologies, coupled with a high risk of bias and substantial heterogeneity, limits the reliability of these findings.</p>

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Aloe Vera Versus Corticosteroids in the Management of Oral Lichen Planus: Systematic Review, Meta-Analysis and GRADE Profile

  • 期刊论文

  • 发表日期：

    2025年7月8日

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  • Simpy Amit Mahuli,
  • Arpita Rai,
  • Md. Munauwar Alam,
  • Shoa Shamsi,
  • Karan Kumar Paswan,
  • Amit Vasant Mahuli,
  • Priya Shree

摘要

Aloe Vera (AV), with its anti-inflammatory and antioxidant properties, has been proposed as an alternative therapy for Oral lichen Planus (OLP). This systematic review and meta-analysis aims to evaluate the efficacy of AV in managing OLP symptoms compared to corticosteroids. A systematic review and meta-analysis were conducted following PRISMA guidelines on the Covidence platform. Databases including PubMed, Lilacs, and EBSCO were searched for studies up to April 2024. Inclusion criteria focused on randomized controlled trials (RCTs) comparing AV to corticosteroids in OLP patients. Risk of bias was assessed using the Cochrane Risk-of-Bias tool 2, and the certainty of evidence was evaluated with the GRADE system. Meta-analysis was performed using Review Manager (RevMan) software. Four RCTs involving 226 patients were included. The meta-analysis revealed no statistically significant difference in VAS scores between AV and corticosteroids (n = 226, MD = 0.09, CI -0.17- 0.58, p = 0.50) with considerable heterogeneity (I² = 74%). Similarly, clinical sign scores showed no significant difference (n = 86, MD = -0.26, CI -1.07, 0.54, p = 0.52, I² = 83%). All included studies were assessed to have a high risk of bias. The GRADE assessment indicated very low certainty of evidence for both outcomes. AV demonstrates comparable efficacy to corticosteroids in reducing pain and improving clinical outcomes in OLP, without reported adverse effects. However, significant variability in AV formulations and study methodologies, coupled with a high risk of bias and substantial heterogeneity, limits the reliability of these findings.