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<p>Lymphoma is the second most common malignancy in the head and neck, following squamous cell carcinoma. It can be classified into Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Extranodal involvement can occur in the salivary glands, nasal cavity, larynx, and oropharyngeal region. Cutaneous B-cell lymphoma (CBCL) is a rare form of NHL and begins as a systemic B-cell lymphoma spread to the skin. We report a rare case of high-grade B-cell lymphoma (HGBCL) of the buccal with CBCL presentation in a patient who presented with painful right buccal swelling for 2 weeks associated with right lower facial swelling for 1 week, left shoulder and supraclavicular swelling with skin discolouration for 2 days. Biopsy of the lesion helps in confirming the disease and hence proper treatment can be started. This case reminds healthcare professionals of the possibility of patients having lymphoma, even though the manifestation of the disease at the oropharyngeal and cutaneous levels is uncommon.</p>

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Extranodal High-Grade B-Cell Lymphoma (HGBCL): A Rare Presentation

  • 期刊论文

  • 发表日期：

    2025年6月18日

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  • Nur Jannah Isdeehar Salahuddin,
  • Luqman Afiq Mohamad Ishak,
  • Azliana Aziz,
  • Siti Zarqah Omar,
  • Norhafiza Mat Lazim

摘要

Lymphoma is the second most common malignancy in the head and neck, following squamous cell carcinoma. It can be classified into Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Extranodal involvement can occur in the salivary glands, nasal cavity, larynx, and oropharyngeal region. Cutaneous B-cell lymphoma (CBCL) is a rare form of NHL and begins as a systemic B-cell lymphoma spread to the skin. We report a rare case of high-grade B-cell lymphoma (HGBCL) of the buccal with CBCL presentation in a patient who presented with painful right buccal swelling for 2 weeks associated with right lower facial swelling for 1 week, left shoulder and supraclavicular swelling with skin discolouration for 2 days. Biopsy of the lesion helps in confirming the disease and hence proper treatment can be started. This case reminds healthcare professionals of the possibility of patients having lymphoma, even though the manifestation of the disease at the oropharyngeal and cutaneous levels is uncommon.