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<p>Solitary fibrous tumor (SFT) is a rare mesenchymal tissue neoplasm that can occur at all anatomic sites, commonly at the pleura. This uncommon mesenchymal tumor can arise in various soft tissues and organs throughout the body, primarily affecting adults and rarely seen in children. In the head &amp; neck region, frequent sites involved are oral cavity, sinonasal tract and orbit. Histopathologically, these tumors are characterized by uniform, spindle-shaped to ovoid fibroblastic cells and a distinctive staghorn vascular pattern. Immunohistochemical analysis reveals that the tumor cells are consistently positive for CD34 and STAT6 in nearly all cases. In this article, we present a rare case of a solitary fibrous tumor located in the mandibular lingual gingiva of a 35-year-old female, with supporting immunohistochemical evidence.</p>

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Solitary Fibrous Tumor of the Oral Cavity: A Rare Entity with Immunohistochemical Profiling

  • 期刊论文

  • 发表日期：

    2025年6月2日

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  • S. Aravindan,
  • Nikita Kashyap,
  • Tathagata Bhattacharjee,
  • S. Srihari,
  • Jay Gopal Ray

摘要

Solitary fibrous tumor (SFT) is a rare mesenchymal tissue neoplasm that can occur at all anatomic sites, commonly at the pleura. This uncommon mesenchymal tumor can arise in various soft tissues and organs throughout the body, primarily affecting adults and rarely seen in children. In the head & neck region, frequent sites involved are oral cavity, sinonasal tract and orbit. Histopathologically, these tumors are characterized by uniform, spindle-shaped to ovoid fibroblastic cells and a distinctive staghorn vascular pattern. Immunohistochemical analysis reveals that the tumor cells are consistently positive for CD34 and STAT6 in nearly all cases. In this article, we present a rare case of a solitary fibrous tumor located in the mandibular lingual gingiva of a 35-year-old female, with supporting immunohistochemical evidence.