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Introduction <p>Laryngopharyngeal reflux (LPR) is a common disease in the outpatient department of otolaryngology and is characterised by backflow of stomach contents into the pharynx and larynx resulting in significant negative impact on the quality of life of patients. The aim of study was to assess the effect of proton pump inhibitor (PPI) on quality of life in patients with LPR.</p> Method <p>110 patients diagnosed with LPR were enrolled in study and prescribed omeprazole (20&#xa0;mg) twice daily for 12 weeks. The Reflux Symptom Index (RSI), Reflux Finding Score (RFS) and LPR–health-related quality of life (HRQOL) were recorded for each patient at the initial visit and at 4th, 8th and 12th week follow-up visits.</p> Results <p>Mean RSI, RFS, HRQOL was 15.28 ± 1.19, 12.65 ± 1.16 and 77.77 ± 11.80 respectively at baseline. Significant improvement was observed in RSI and RFS scores after treatment. The HRQOL score also showed gradual improvement after PPI treatment.</p> Conclusion <p>PPI treatment brought about a significant improvement in signs, symptoms and quality of life of LPR patients.</p>

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Effect of Proton Pump Inhibitor on Quality of Life of Patients with Laryngopharyngeal Reflux

  • 期刊论文

  • 发表日期：

    2025年6月5日

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  • Kriti Bhatt,
  • Rajeev Krishna Gupta,
  • Anuja Bhargava,
  • S.M. Faiz,
  • Saurabh Srivastava,
  • Eshani Dutta,
  • Abdul Khalid

摘要

Introduction

Laryngopharyngeal reflux (LPR) is a common disease in the outpatient department of otolaryngology and is characterised by backflow of stomach contents into the pharynx and larynx resulting in significant negative impact on the quality of life of patients. The aim of study was to assess the effect of proton pump inhibitor (PPI) on quality of life in patients with LPR.

Method

110 patients diagnosed with LPR were enrolled in study and prescribed omeprazole (20 mg) twice daily for 12 weeks. The Reflux Symptom Index (RSI), Reflux Finding Score (RFS) and LPR–health-related quality of life (HRQOL) were recorded for each patient at the initial visit and at 4th, 8th and 12th week follow-up visits.

Results

Mean RSI, RFS, HRQOL was 15.28 ± 1.19, 12.65 ± 1.16 and 77.77 ± 11.80 respectively at baseline. Significant improvement was observed in RSI and RFS scores after treatment. The HRQOL score also showed gradual improvement after PPI treatment.

Conclusion

PPI treatment brought about a significant improvement in signs, symptoms and quality of life of LPR patients.