<p>In the “post-poverty alleviation era,” rural tourism serves as a key strategy for preventing large-scale return to poverty and promoting rural revitalization in western minority regions. This study constructs a structural equation model to analyze the comprehensive effect of preventing return to poverty of rural tourism from three dimensions: economic income, social culture and living environment in Naxi Ethnic Township, Markam County, Tibet. On this basis, it analyses the “core-periphery” spatial differentiation characteristics and the influence mechanism of effect of preventing return to poverty of rural tourism. The results show that: ①Rural tourism has an obvious effect of preventing return to poverty. Which not only consolidates the channels for off-poverty population to obtain high income sources, but also innovates the self-development ability of off-poverty population, and it leads the fashion of off-poverty population to pursue high-quality life. ②The effect of preventing return to poverty in the core and the periphery does not follow a single spatial distance attenuation law, but presents a multidimensional and multivariate spatial imbalance distribution: economic income “core high-periphery low”, social culture “core high-periphery low” and human settlements “core low-periphery high”. ③Through economic “demonstration”, social “diffusion” and environmental “demonstration”, the core area realizes the “core-periphery” integrated effect of preventing return to poverty.</p>