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<p>Hydroxyapatite (HA) and tricalcium phosphate (TCP), two common calcium phosphate-based bioceramics, are widely utilized in biomedical fields like tissue scaffolding, controlled drug release, and chromatographic processes. Biphasic calcium phosphates (BCPs), which consist of HA and TCP at different ratios, have been developed to enhance the bioactivity and offer superior bone repair capabilities compared to those of pure HA or β-TCP. To enhance the functionality of BCPs, incorporating elements like boron (B) has drawn increasing attention because of its positive influence on bone regeneration. In this study, BCPs containing different concentrations of boron were produced through two distinct approaches: wet chemical synthesis and solid-state synthesis. While previous research has explored the effects of boron incorporation in calcium phosphate-based materials, comparative studies focusing specifically on these two synthesis methods remain limited. Therefore, this work aims to fill that gap by evaluating the biocompatibility of the produced samples through cell adhesion and viability assays using human fetal osteoblast (hFOB) cells. The findings revealed that boron doping increased cell proliferation, and samples synthesized via the solid-state method presented superior biological results. These results highlight the importance of the synthesis method in shaping the biological behavior of boron doped BCP materials.</p>

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Biological activity assessment of boron content and synthesis method on boron-doped biphasic calcium phosphate

  • 期刊论文

  • 发表日期：

    2026年2月9日

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  • Seyma Gulnaz Yarlilar,
  • Birgul Mazmanci,
  • Onder Albayrak

摘要

Hydroxyapatite (HA) and tricalcium phosphate (TCP), two common calcium phosphate-based bioceramics, are widely utilized in biomedical fields like tissue scaffolding, controlled drug release, and chromatographic processes. Biphasic calcium phosphates (BCPs), which consist of HA and TCP at different ratios, have been developed to enhance the bioactivity and offer superior bone repair capabilities compared to those of pure HA or β-TCP. To enhance the functionality of BCPs, incorporating elements like boron (B) has drawn increasing attention because of its positive influence on bone regeneration. In this study, BCPs containing different concentrations of boron were produced through two distinct approaches: wet chemical synthesis and solid-state synthesis. While previous research has explored the effects of boron incorporation in calcium phosphate-based materials, comparative studies focusing specifically on these two synthesis methods remain limited. Therefore, this work aims to fill that gap by evaluating the biocompatibility of the produced samples through cell adhesion and viability assays using human fetal osteoblast (hFOB) cells. The findings revealed that boron doping increased cell proliferation, and samples synthesized via the solid-state method presented superior biological results. These results highlight the importance of the synthesis method in shaping the biological behavior of boron doped BCP materials.