<p>The hydrocarbon (HC) refrigerants in an HC compressor based vapour compression refrigeration system (VCRS) enhance performance and reduce environmental impact compared to retrofitted systems. In this study, procured SiO₂ and TiO₂ nanoparticles in various proportions were dispersed in polyolester (POE) oil to prepare mono and hybrid nano-oils. The stability of prepared nano-oils was analyzed using Zeta potential measurements. These nano-oils were then employed as compressor oil in a refrigeration test rig to reduce compressor power consumption (CPC) and enhance refrigeration effect and coefficient of performance (COP). R600a, a well-performing HC refrigerant, was considered in this study. The field emission scanning electron microscope (FE-SEM) and X-ray diffractometer were used to confirm the shape and crystal structure of nanoparticles, respectively. The mono and hybrid nano-oils outperformed the POE oil. Additionally, the hybrid nano-oils show better results than mono nano-oil samples, except for one hybrid nano-oil sample with an equal proportion of TiO₂ and SiO₂ nanoparticles. Among all oil samples, the hybrid nano-oil sample with 75% SiO₂ and 25% TiO₂ nanoparticles exhibits the best performance, exhibits more than an 8% average CPC reduction, a 12% average RE enhancement, and more than 21%. increase in the average COP, compared to the base oil. The compressor characteristics (pressure ratio, inlet, and outlet temperatures) and pull-down temperatures (for 150 minutes) were analyzed to confirm the effect of nano-oil samples on VCRS performance. Tribological and thermophysical tests of each oil sample at various test temperatures confirmed their sustainable lubricating properties at higher operating temperatures.</p>