<p>Pedigree is a more systematic and scientific record of family history which has proved to be an invaluable tool in the hands of human geneticists. In fact, even before human genetics was established as a proper science and the rules of inheritance were formulated, such recordings of familial traits were used across several generations to identify diseases running through generations within families. Pedigree analysis not only facilitates verification of the hereditary nature of a feature but also enables interpretation of its genetic etiology. Pedigree also comes in handy in explaining the complexities of inheritance of features such as incomplete penetrance, genomic imprinting, and anticipation. It also has high predictive value regarding the recurrence of disease in the family. Pedigree analysis thus becomes the most economical, simple and elementary tool in the hands of the human geneticists.</p>

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Pedigree Analysis in Medical Genetics

  • Rajiva Raman

摘要

Pedigree is a more systematic and scientific record of family history which has proved to be an invaluable tool in the hands of human geneticists. In fact, even before human genetics was established as a proper science and the rules of inheritance were formulated, such recordings of familial traits were used across several generations to identify diseases running through generations within families. Pedigree analysis not only facilitates verification of the hereditary nature of a feature but also enables interpretation of its genetic etiology. Pedigree also comes in handy in explaining the complexities of inheritance of features such as incomplete penetrance, genomic imprinting, and anticipation. It also has high predictive value regarding the recurrence of disease in the family. Pedigree analysis thus becomes the most economical, simple and elementary tool in the hands of the human geneticists.