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<p>In recent decades, the early diagnosis of cancerous tumours has become increasingly crucial, facilitating timely detection, effective treatment and improved prognosis. This paper proposes a compact and portable metamaterial-assisted terahertz (THz) biosensor design for early breast cancer cell detection. The proposed metasurface-based biosensor differentiates between normal and cancerous cells loaded onto its surface by analysing variations in the refractive index. The absorption spectra of the bare biosensor demonstrate three distinct peaks at 1.6043, 2.2756 and 2.8734 THz, with corresponding absorption coefficients of 0.9990, 0.9714 and 0.6456, respectively. On deploying the biosensor for cancer cell sensing, a frequency shift of 9.8 GHz and a theoretical sensitivity of 700 GHz per refractive index unit (GHz/RIU) is observed. The biosensor effectively differentiates cancerous cells from normal cells in simulation, demonstrating strong potential for use in future cancer detection and characterization studies. Furthermore, the impact of analyte thickness, dielectric thickness and various dielectric materials on the performance of the biosensor is thoroughly investigated. Consequently, the proposed THz biosensor demonstrates strong potential for early cancer cell detection.</p>

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Design and analysis of a terahertz-based biosensor for rapid breast cancer cell detection

  • 期刊论文

  • 发表日期：

    2026年3月30日

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  • Meraline Selvaraj,
  • Sreeja B S

摘要

In recent decades, the early diagnosis of cancerous tumours has become increasingly crucial, facilitating timely detection, effective treatment and improved prognosis. This paper proposes a compact and portable metamaterial-assisted terahertz (THz) biosensor design for early breast cancer cell detection. The proposed metasurface-based biosensor differentiates between normal and cancerous cells loaded onto its surface by analysing variations in the refractive index. The absorption spectra of the bare biosensor demonstrate three distinct peaks at 1.6043, 2.2756 and 2.8734 THz, with corresponding absorption coefficients of 0.9990, 0.9714 and 0.6456, respectively. On deploying the biosensor for cancer cell sensing, a frequency shift of 9.8 GHz and a theoretical sensitivity of 700 GHz per refractive index unit (GHz/RIU) is observed. The biosensor effectively differentiates cancerous cells from normal cells in simulation, demonstrating strong potential for use in future cancer detection and characterization studies. Furthermore, the impact of analyte thickness, dielectric thickness and various dielectric materials on the performance of the biosensor is thoroughly investigated. Consequently, the proposed THz biosensor demonstrates strong potential for early cancer cell detection.