<p>Recent studies on luminescence characters of sediments have proved its application as a proxy to decipher earth surficial processes and Late Quaternary palaeoclimatic reconstruction. In the present study, first time we have attempted its application to address Late Quaternary palaeoclimatic changes in the Antarctic Ice-free area, evaluating the measured luminescence sensitivity (LS) from an 86.5 cm sediment core retrieved during 41^st Indian Scientific Expedition to Antarctica (41^st ISEA) from Nella Lake, Brokness Peninsula, Larsemann Hills, East Antarctica. The continuous downcore LS variation from conjugate samples (n=44) at 2 cm depth shows a marked distinct sensitivity plateau with minor fluctuations that depicts the transition from warm-humid phase during end of MIS-3 (Zone-1; Interglacial; &gt;22 ka) to cold-arid phase during MIS-2 (Zone-2; LGM transition). Whereas, the Holocene period (Zone-3; post ~11 ka) is characterised by comparatively higher magnitude LS counts/Gy/g, forming a distinct plateau with consistently similar sensitivity comparable to corresponding values in MIS-3 (end phase) represented in the sediment core. The characteristic sedimentary facies and depositional environment support the luminescence variation-based inferences that signify the variable strength of surficial processes depicting warm and cold periods. The study highlights that the luminescence sensitivity variation can be used as a proxy to decipher the Late Quaternary changes in Earth's surficial processes and palaeoclimatic conditions, even in the small catchment fluvio-lacustrine environment of Antarctic Ice-free domain.</p>