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<p>The pharmacological potential of six newly synthesized organotin(IV) carboxylates is reported. For the synthesis of complexes, R<sub>3</sub>SnCl/R<sub>2</sub>SnCl<sub>2</sub> were reacted with sodium carboxylate salt <b>NaL</b> in dry chloroform {R = <i>n</i>-C<sub>4</sub>H<sub>9</sub> (<b>1</b>,<b> 4</b>), CH<sub>3</sub> (<b>2</b>, <b>5</b>), C<sub>6</sub>H<sub>5</sub> (<b>3</b>, <b>6</b>) and L = 2,4-dichlorophenylacetate}. Microanalysis has validated the expected elemental composition of the complexes. FT-IR spectra suggested chelating/bridging bidentate coordination of the ligand in the complexes. A distorted trigonal-bipyramidal geometry around the Sn-atom was confirmed by single-crystal analysis in complex <b>1</b>. The <sup>1</sup>H and <sup>13</sup>C NMR spectra have shown signals in the expected regions. <i>In vitro</i> studies have shown excellent biological potential of the complexes <b>1</b>–<b>6</b> than the ligand acid <b>HL</b>, with few exceptions. Among complexes, <b>1</b>, <b>3</b> and <b>4</b> have shown promising anticancer potential against the U-87 cell line. Complex <b>5</b> was the most efficient COX-2, AChE and BChE inhibitor. Similarly, <b>1</b> has shown relatively lower IC<sub>50</sub> values against α-glucosidase and α-amylase. All complexes, except <b>1</b>, were more active scavengers of DPPH as compared to ABTS radicals. The antileishmanial potential of<b> 1</b> was higher than the standard, Amphotericin B. Complex <b>1</b> has also shown better activity against <i>P. aeruginosa</i> and <i>C. albicans</i> as compared to the standard.</p> Graphical Abstract <p>Six organotin(IV) derivatives of 2,4-dichlorophenylacetic acid are synthesized. Composition and structural analyses of the complexes were made by elemental analysis, FT-IR, NMR and single crystal XRD analysis. <i>In vitro</i> anticancer, enzyme inhibition, antioxidant, antileishmanial and antimicrobial potential of the synthesized complexes was evaluated.</p>

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Multimodal pharmacological potential of newly synthesized organotin(IV) derivatives of 2,4-dichlorophenyl acetic acid

  • 期刊论文

  • 发表日期：

    2026年2月18日

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  • Shahnaz Rahim,
  • Ishaq N. Khan,
  • Abdul Sadiq,
  • Aiman Saeed,
  • Nighat Fatima,
  • Maciej Kubicki,
  • Benson Kariuki,
  • Niaz Muhammad,
  • Momin Khan,
  • Awal Noor,
  • Sadaf Qayyum

摘要

The pharmacological potential of six newly synthesized organotin(IV) carboxylates is reported. For the synthesis of complexes, R3SnCl/R2SnCl2 were reacted with sodium carboxylate salt NaL in dry chloroform {R = n-C4H9 (1, 4), CH3 (2, 5), C6H5 (3, 6) and L = 2,4-dichlorophenylacetate}. Microanalysis has validated the expected elemental composition of the complexes. FT-IR spectra suggested chelating/bridging bidentate coordination of the ligand in the complexes. A distorted trigonal-bipyramidal geometry around the Sn-atom was confirmed by single-crystal analysis in complex 1. The 1H and 13C NMR spectra have shown signals in the expected regions. In vitro studies have shown excellent biological potential of the complexes 1–6 than the ligand acid HL, with few exceptions. Among complexes, 1, 3 and 4 have shown promising anticancer potential against the U-87 cell line. Complex 5 was the most efficient COX-2, AChE and BChE inhibitor. Similarly, 1 has shown relatively lower IC50 values against α-glucosidase and α-amylase. All complexes, except 1, were more active scavengers of DPPH as compared to ABTS radicals. The antileishmanial potential of 1 was higher than the standard, Amphotericin B. Complex 1 has also shown better activity against P. aeruginosa and C. albicans as compared to the standard.

Graphical Abstract

Six organotin(IV) derivatives of 2,4-dichlorophenylacetic acid are synthesized. Composition and structural analyses of the complexes were made by elemental analysis, FT-IR, NMR and single crystal XRD analysis. In vitro anticancer, enzyme inhibition, antioxidant, antileishmanial and antimicrobial potential of the synthesized complexes was evaluated.