<p>Poly(4-vinylbenzyl-graft-ethylene glycol methyl ether) (poly(VB-g-mPEG)) amphiphilic graft copolymer was obtained using ‘click’ chemistry of polyethylene glycol methyl ether propargyl (mPEG-propargyl) and terminal azido poly(4-vinylbenzyl chloride) (PVB-N₃). Using 2,2′-azobis(2-methylpropionitrile) and 4-vinylbenzyl chloride, poly(4-vinylbenzyl chloride) (PVBC) was created by free-radical polymerization (FRP). PVB-N₃ was obtained using PVBC and sodium azide. Propargyl chloride and polyethylene glycol methyl ether were reacted to form mPEG-propargyl. The ‘click’ chemical method created poly(VB-g-mPEG) amphiphilic graft copolymer by reacting PVB-N₃ with mPEG-propargyl. ¹H-NMR, DSC, FTIR and GPC characterized the products. The spectroscopic and thermal studies monitored that poly(VB-g-mPEG) was built via combining FRP and ‘click’ chemistry.</p> Graphical Abstract <p>The synthesis of poly(4-vinylbenzyl-graft-ethylene glycol methyl ether) amphiphilic graft copolymer was demonstrated in this study by using “click” chemistry and free radical polymerization. The synthesized products were characterized by using ¹H-NMR, DSC, FT-IR, and GPC instruments. Here, we aimed to report on synthesizing the amphiphilic graft copolymer using “click” chemistry and free radical polymerization methods.</p> <p></p>