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<p>A facile and efficient synthesis of polysubstituted pyridin-2(1<i>H</i>)-ones has been developed <i>via</i> a formal [4+2] annulation of readily available <i>α</i>-functionalized <i>β</i>-aminoacrylamides and malononitrile in the presence of potassium carbonate (K<sub>2</sub>CO<sub>3</sub>) in dimethylsulfoxide (DMSO).</p> Graphical abstract <p></p>

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Formal [4+2] annulation of β-aminoacrylamides and malononitrile: a synthetic route to substituted pyridin-2(1H)-ones

  • 期刊论文

  • 发表日期：

    2025年4月17日

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  • Xin Liu,
  • Jiawang Li,
  • Rui Zhang,
  • Dewen Dong

摘要

A facile and efficient synthesis of polysubstituted pyridin-2(1H)-ones has been developed via a formal [4+2] annulation of readily available α-functionalized β-aminoacrylamides and malononitrile in the presence of potassium carbonate (K2CO3) in dimethylsulfoxide (DMSO).

Graphical abstract