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<p>This study investigated the effects of coenzyme Q10 (CoQ10) administration on fibromyalgia (FM) symptoms and cognitive functions in a reserpine-induced FM model. It is also aimed to evaluate the role of the PGC-1α/FNDC5/BDNF pathway and oxidative stress in this process. Female Wistar rats were randomly assigned to control, FM, CoQ10, and FM + CoQ10 groups. The FM groups received daily subcutaneous reserpine (1&#xa0;mg&#xa0;kg<sup>−1</sup>) for three consecutive days. The CoQ10 groups were administered 150&#xa0;mg&#xa0;kg<sup>−1</sup> of oral CoQ10 for 7&#xa0;days. Behavioral and sensory assessments were conducted on days 0, 4, and 6. Mechanical allodynia was measured with the Von Frey test, while depressive-like behavior was assessed using the forced swim test. Locomotor activity and anxiety levels were evaluated via the elevated plus maze, and learning/memory performance were tested using the Morris water maze probe test. Reserpine exposure led to increased mechanical allodynia, decreased locomotor activity, elevated anxiety levels, increased depressive-like behavior, and impaired learning/memory (<i>p</i> &lt; 0.05). These behavioral abnormalities were accompanied by decreased hippocampal levels of CoQ9 and CoQ10, increased oxidative stress, and reduced antioxidant defenses (<i>p</i> &lt; 0.05). Additionally, hippocampal PGC-1α, FNDC5 and BDNF expression levels were reduced (<i>p</i> &lt; 0.05). CoQ10 treatment resulted in significant improvements in these neuropathological parameters (<i>p</i> &lt; 0.05). These results imply that CoQ10 can counteract the behavioral, biochemical, and molecular disturbances characteristic of FM. The mechanism is suggested to involve stimulating the PGC-1α/FNDC5/BDNF cascade, which in turn reduces behavioral deficits linked to pain, depression, and cognitive function.</p>

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Coenzyme Q10 Ameliorates Fibromyalgia-like Symptoms and Cognitive Deficits by Enhancing Hippocampal PGC-1α/FNDC5/BDNF Pathway in Reserpine-Treated Rats

  • 期刊论文

  • 发表日期：

    2025年12月4日

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  • Muaz Belviranlı,
  • Nilsel Okudan,
  • Tuğba Sezer

摘要

This study investigated the effects of coenzyme Q10 (CoQ10) administration on fibromyalgia (FM) symptoms and cognitive functions in a reserpine-induced FM model. It is also aimed to evaluate the role of the PGC-1α/FNDC5/BDNF pathway and oxidative stress in this process. Female Wistar rats were randomly assigned to control, FM, CoQ10, and FM + CoQ10 groups. The FM groups received daily subcutaneous reserpine (1 mg kg−1) for three consecutive days. The CoQ10 groups were administered 150 mg kg−1 of oral CoQ10 for 7 days. Behavioral and sensory assessments were conducted on days 0, 4, and 6. Mechanical allodynia was measured with the Von Frey test, while depressive-like behavior was assessed using the forced swim test. Locomotor activity and anxiety levels were evaluated via the elevated plus maze, and learning/memory performance were tested using the Morris water maze probe test. Reserpine exposure led to increased mechanical allodynia, decreased locomotor activity, elevated anxiety levels, increased depressive-like behavior, and impaired learning/memory (p < 0.05). These behavioral abnormalities were accompanied by decreased hippocampal levels of CoQ9 and CoQ10, increased oxidative stress, and reduced antioxidant defenses (p < 0.05). Additionally, hippocampal PGC-1α, FNDC5 and BDNF expression levels were reduced (p < 0.05). CoQ10 treatment resulted in significant improvements in these neuropathological parameters (p < 0.05). These results imply that CoQ10 can counteract the behavioral, biochemical, and molecular disturbances characteristic of FM. The mechanism is suggested to involve stimulating the PGC-1α/FNDC5/BDNF cascade, which in turn reduces behavioral deficits linked to pain, depression, and cognitive function.