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<p>G protein-coupled receptors (GPCRs), comprising the largest family of membrane receptors in humans, play a crucial roles in various physiological and pathological processes. Although several drugs that target GPCRs have been discovered, the characterization of orphan GPCRs (oGPCRs) remains a significant challenge. Despite extensive research, knowledge on a significant portion of these receptors, along with their ligands and target sites, remains undefined. GPR88 belongs to the category of oGPCR that is expressed in various tissues and organs, with numerous studies indicating that it plays a regulatory role in cognitive processes, emotional responses, and motor control, thereby influencing various brain behaviors and functions associated with learning. Therefore, the purpose of this review was to thoroughly examine the role of GPR88 in various central nervous system diseases, with the ultimate aim of positioning it as a potential and promising target for drug development, particularly for the treatment of a broad spectrum of neurological disorders.</p>

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Orphan G Protein-Coupled Receptor GPR88: Mapping Its Significance in Central Nervous System Disorders

  • 期刊论文

  • 发表日期：

    2025年4月4日

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  • Yanli Zhao,
  • Dongxu Yue,
  • Yingying Zou

摘要

G protein-coupled receptors (GPCRs), comprising the largest family of membrane receptors in humans, play a crucial roles in various physiological and pathological processes. Although several drugs that target GPCRs have been discovered, the characterization of orphan GPCRs (oGPCRs) remains a significant challenge. Despite extensive research, knowledge on a significant portion of these receptors, along with their ligands and target sites, remains undefined. GPR88 belongs to the category of oGPCR that is expressed in various tissues and organs, with numerous studies indicating that it plays a regulatory role in cognitive processes, emotional responses, and motor control, thereby influencing various brain behaviors and functions associated with learning. Therefore, the purpose of this review was to thoroughly examine the role of GPR88 in various central nervous system diseases, with the ultimate aim of positioning it as a potential and promising target for drug development, particularly for the treatment of a broad spectrum of neurological disorders.