Scholarlink

<p>Endometrial cancer remains a major health concern, underscoring the need for advanced diagnostic and therapeutic strategies. In this study, a multifunctional chitosan-based fluorescent nanoplatform (CS-1@FA) was rationally designed by functionalizing chitosan with a plant-derived modifier (Compound 1) and subsequently loading ferulic acid (FA). Unlike conventional chitosan- or FA-based nanosystems, CS-1@FA integrates intrinsic fluorescence, ratiometric metal-ion sensing, and enhanced bioactivity within a single platform. The resulting nanocomposite exhibited stable photoluminescence with excellent pH and thermal stability, enabling sensitive and selective fluorescence and ratiometric detection of FA and Al<sup>3+</sup> ions. Furthermore, cell viability assays demonstrated good biocompatibility and a markedly enhanced inhibitory effect of FA-loaded nanoparticles on endometrial cancer cells compared with free FA. Overall, these findings highlight CS-1@FA as a versatile fluorescent nanoplatform that combines fluorescence sensing capability with biological activity, offering a promising material strategy for disease-related metal ion detection and nanomedicine-oriented applications.</p> Graphical abstract <p>The design, fluorescence sensing functions, and anticancer activity of the multifunctional CS-1@FA nanoplatform, integrating FA loading, selective Al³⁺ sensing, and regulation of cancer-related signaling pathways.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Ferulic acid-loaded fluorescent chitosan nanoplatform for Al3+/FA sensing and bioactivity against endometrial cancer

  • 期刊论文

  • 发表日期：

    2026年6月16日

查看全文
  • Jia Ye,
  • Wen Xi,
  • Lingli Huang,
  • Yang Zhang,
  • Qingsong Zhang,
  • Qianqian Wang,
  • Jinwei Zhang

摘要

Endometrial cancer remains a major health concern, underscoring the need for advanced diagnostic and therapeutic strategies. In this study, a multifunctional chitosan-based fluorescent nanoplatform (CS-1@FA) was rationally designed by functionalizing chitosan with a plant-derived modifier (Compound 1) and subsequently loading ferulic acid (FA). Unlike conventional chitosan- or FA-based nanosystems, CS-1@FA integrates intrinsic fluorescence, ratiometric metal-ion sensing, and enhanced bioactivity within a single platform. The resulting nanocomposite exhibited stable photoluminescence with excellent pH and thermal stability, enabling sensitive and selective fluorescence and ratiometric detection of FA and Al3+ ions. Furthermore, cell viability assays demonstrated good biocompatibility and a markedly enhanced inhibitory effect of FA-loaded nanoparticles on endometrial cancer cells compared with free FA. Overall, these findings highlight CS-1@FA as a versatile fluorescent nanoplatform that combines fluorescence sensing capability with biological activity, offering a promising material strategy for disease-related metal ion detection and nanomedicine-oriented applications.

Graphical abstract

The design, fluorescence sensing functions, and anticancer activity of the multifunctional CS-1@FA nanoplatform, integrating FA loading, selective Al³⁺ sensing, and regulation of cancer-related signaling pathways.