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<p>Green-synthesized nanoparticles provide an eco-friendly approach to nanotechnology, reducing harmful chemical use and environmental impact. This study focuses on the green synthesis of nickel oxide nanoparticles (FV-NiO NPs) using <i>Fioria vitifolia</i>. Synthesized NPs were characterization by UV, XRD, FTIR, SEM, and TEM revealed spherical, well-dispersed particles (17–168&#xa0;nm) with a UV–Visible absorption peak at 247&#xa0;nm. EDAX analysis confirmed their composition: 55.02% Ni, 22.77% O, 18.49% C, and 3.71% Na. FV-NiO NPs exhibited potent antibacterial activity at 100&#xa0;µg/mL against <i>Escherichia coli</i> (21.1 ± 0.2&#xa0;mm inhibition) and <i>Enterococcus faecalis</i> (24.6 ± 0.5&#xa0;mm inhibition). Furthermore, anti-inflammatory activity showed 68.3% inhibition at 200&#xa0;µg/mL, while antioxidant assays demonstrated 78.64% DPPH and 68.21% ABTS inhibition at 100&#xa0;µg/mL. Antitumour assays revealed an IC<sub>50</sub> of 28.15&#xa0;µg/mL against A549 lung cancer cells. Photocatalytic studies indicated 88.9% degradation efficiency of Reactive Black 5 dye under visible light. Zebrafish embryo assays demonstrated dose-dependent toxicity, influencing body length, heart rate, hatchability, and survival rates, confirming the nanoparticles’ biosafety. These results highlight FV-NiO NPs as promising candidates for biomedical and environmental applications.</p>

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Biogenic Nickel Oxide Nanoparticles: Synthesis, Characterization and Biomedical Potential

  • 期刊论文

  • 发表日期：

    2025年3月5日

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  • Akankshya Dash,
  • Chinnasamy Ragavendran,
  • Ranjith Rajendran

摘要

Green-synthesized nanoparticles provide an eco-friendly approach to nanotechnology, reducing harmful chemical use and environmental impact. This study focuses on the green synthesis of nickel oxide nanoparticles (FV-NiO NPs) using Fioria vitifolia. Synthesized NPs were characterization by UV, XRD, FTIR, SEM, and TEM revealed spherical, well-dispersed particles (17–168 nm) with a UV–Visible absorption peak at 247 nm. EDAX analysis confirmed their composition: 55.02% Ni, 22.77% O, 18.49% C, and 3.71% Na. FV-NiO NPs exhibited potent antibacterial activity at 100 µg/mL against Escherichia coli (21.1 ± 0.2 mm inhibition) and Enterococcus faecalis (24.6 ± 0.5 mm inhibition). Furthermore, anti-inflammatory activity showed 68.3% inhibition at 200 µg/mL, while antioxidant assays demonstrated 78.64% DPPH and 68.21% ABTS inhibition at 100 µg/mL. Antitumour assays revealed an IC50 of 28.15 µg/mL against A549 lung cancer cells. Photocatalytic studies indicated 88.9% degradation efficiency of Reactive Black 5 dye under visible light. Zebrafish embryo assays demonstrated dose-dependent toxicity, influencing body length, heart rate, hatchability, and survival rates, confirming the nanoparticles’ biosafety. These results highlight FV-NiO NPs as promising candidates for biomedical and environmental applications.