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<p>Neuronal excitatory activity promotes glioma progression through glutamate-mediated signaling, yet effective ways to counter this using intrinsic brain mechanisms remain undefined. Repeated low-frequency neuronal stimulation can lead to glutamate buildup and pathway-specific activation of inhibitory presynaptic metabotropic glutamate receptors (mGluRs) within neural circuits. This perspective introduces a hypothesis that this mechanism can disrupt tumor-promoting neuron-glioma interactions. This direction introduces a biologically grounded strategy for a distinctive therapeutic path in precision neuro-oncology.</p>

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Inhibitory glutamatergic feedback for brain tumor therapy

  • 期刊论文

  • 发表日期：

    2026年1月20日

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  • Ray X. Lee

摘要

Neuronal excitatory activity promotes glioma progression through glutamate-mediated signaling, yet effective ways to counter this using intrinsic brain mechanisms remain undefined. Repeated low-frequency neuronal stimulation can lead to glutamate buildup and pathway-specific activation of inhibitory presynaptic metabotropic glutamate receptors (mGluRs) within neural circuits. This perspective introduces a hypothesis that this mechanism can disrupt tumor-promoting neuron-glioma interactions. This direction introduces a biologically grounded strategy for a distinctive therapeutic path in precision neuro-oncology.