Scholarlink

<p>Hepatocellular carcinoma (HCC), a prevalent and lethal cancer worldwide, is driven by complex molecular mechanisms. Post-translational modifications (PTMs) crucially influence protein function, stability, and signaling, affecting metabolic reprogramming, cell cycle control, immune evasion, and tumor microenvironment (TME) changes in HCC. Recent studies have increasingly examined various PTMs in HCC, notably phosphorylation, ubiquitination, methylation, glycosylation, acetylation, lactylation, and SUMOylation. These modifications affect key proteins like GPX4, CDK5, PHGDH, GLS1, and HIF-1α, playing roles in cancer development, spread, and treatment resistance. Despite progress, challenges remain in understanding PTMs and applying them clinically. This review aims to summarize recent PTM research in HCC, evaluate their therapeutic potential, and propose strategies for precision therapies in HCC.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Post-translational modifications in hepatocellular carcinoma: mechanisms and therapeutic potential

  • 期刊论文

  • 发表日期：

    2025年10月18日

查看全文
  • Jianqi Qin,
  • Weixiong Zhu,
  • Zengxi Yang,
  • Shuze Zhang,
  • Wence Zhou

摘要

Hepatocellular carcinoma (HCC), a prevalent and lethal cancer worldwide, is driven by complex molecular mechanisms. Post-translational modifications (PTMs) crucially influence protein function, stability, and signaling, affecting metabolic reprogramming, cell cycle control, immune evasion, and tumor microenvironment (TME) changes in HCC. Recent studies have increasingly examined various PTMs in HCC, notably phosphorylation, ubiquitination, methylation, glycosylation, acetylation, lactylation, and SUMOylation. These modifications affect key proteins like GPX4, CDK5, PHGDH, GLS1, and HIF-1α, playing roles in cancer development, spread, and treatment resistance. Despite progress, challenges remain in understanding PTMs and applying them clinically. This review aims to summarize recent PTM research in HCC, evaluate their therapeutic potential, and propose strategies for precision therapies in HCC.