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<p>This study investigates the cytotoxic effects of <i>R. tridentat</i>a extracts on prostate cancer cells, providing insight into its potential therapeutic benefits and scientific validation for its traditional use in cancer treatment. The cytotoxicity of <i>R. tridentata</i> extracts was evaluated on prostate cancer cell lines (LNCaP and DU 145) using the MTT assay, with doxorubicin as a reference standard. Our findings demonstrated significant concentration- and time-dependent cytotoxic effects of the extracts on both cell lines (<i>p</i> &lt; 0.0024 to <i>p</i> &lt; 0.0002). Notably, the methanol extract exhibited potent cytotoxicity, with IC<sub>50</sub> values ranging from 124.07 to 211&#xa0;μg/mL (DU145) and 100 to 180&#xa0;μg/ml (LNCaP) over 24–72&#xa0;h (<i>p</i> &lt; 0.0024 to <i>p</i> &lt; 0.0001), highlighting its therapeutic potential. This study unveils the promising cytotoxic activity of <i>R. tridentata</i> extracts, particularly methanol extracts, against prostate cancer cells, showcasing their concentration- and time-dependent effects. These findings underscore the potential of plant-derived extracts as therapeutic agents for cancer treatment, warranting further research.</p>

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Exploring the anticancer potential of R. tridentata extracts: a cytotoxicity study against human prostate cancer cell lines (LNCaP and DU145)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月5日

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  • Ali Kudamba,
  • Godfrey S. Bbosa,
  • Allan Lugaajju,
  • Henry Wabinga,
  • Nixon Niyonzima,
  • Moses Ocan,
  • Ali M. Damani,
  • Hussein M. Kafeero,
  • Jamilu E. Ssenku,
  • Shaban A. Okurut,
  • Muniiru Lubowa,
  • Abdul Walusansa,
  • S. Sivagami Sivasundaram,
  • Shobana Shampath,
  • Haruna Muwonge

摘要

This study investigates the cytotoxic effects of R. tridentata extracts on prostate cancer cells, providing insight into its potential therapeutic benefits and scientific validation for its traditional use in cancer treatment. The cytotoxicity of R. tridentata extracts was evaluated on prostate cancer cell lines (LNCaP and DU 145) using the MTT assay, with doxorubicin as a reference standard. Our findings demonstrated significant concentration- and time-dependent cytotoxic effects of the extracts on both cell lines (p < 0.0024 to p < 0.0002). Notably, the methanol extract exhibited potent cytotoxicity, with IC50 values ranging from 124.07 to 211 μg/mL (DU145) and 100 to 180 μg/ml (LNCaP) over 24–72 h (p < 0.0024 to p < 0.0001), highlighting its therapeutic potential. This study unveils the promising cytotoxic activity of R. tridentata extracts, particularly methanol extracts, against prostate cancer cells, showcasing their concentration- and time-dependent effects. These findings underscore the potential of plant-derived extracts as therapeutic agents for cancer treatment, warranting further research.