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<p>MicroRNAs (miRNAs) are essential post-transcriptional regulators of gene expression involved in a broad range of biological activities. Recent studies have increasingly highlighted their significant role in the development and progression of various human cancers. Among these, miR-362 has emerged as a context-dependent molecule, exhibiting both oncogenic and tumor-suppressive functions across different malignancies. Elevated levels of miR-362 have been associated to tumor-promoting effects in several cancers. In contrast, its downregulation in some other carcinoma is associated with disease progression, suggesting a tumor-suppressive role. These opposing functions underscore miR-362 involvement in complex regulatory networks and supports its potential as a biomarker for diagnosis, prognosis, and possibly therapeutic intervention. This review aims to provide an overview of the current understanding of miR-362 expression patterns, molecular targets, regulatory mechanisms, and its dual role in cancer biology, with the goal of clarifying its clinical significance in cancer diagnosis, prognosis, and therapy. </p> Graphical Abstract <p>The specific targets of miR-362 across various malignancies</p> <p></p>

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The emerging role of miR-362 in cancer: expression and function across different cancer types

  • 期刊论文

  • 发表日期：

    2025年7月26日

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  • Shahad Mohammed Dhiaa Younis,
  • Abdulkareem Shareef,
  • Lalji Baldaniya,
  • Rami Oweis,
  • S. Renuka Jyothi,
  • Udaybir Singh,
  • Samir Sahoo,
  • Ashish Singh Chauhan,
  • Hayder Naji Sameer,
  • Ahmed Yaseen,
  • Zainab H. Athab,
  • Mohaned Adil

摘要

MicroRNAs (miRNAs) are essential post-transcriptional regulators of gene expression involved in a broad range of biological activities. Recent studies have increasingly highlighted their significant role in the development and progression of various human cancers. Among these, miR-362 has emerged as a context-dependent molecule, exhibiting both oncogenic and tumor-suppressive functions across different malignancies. Elevated levels of miR-362 have been associated to tumor-promoting effects in several cancers. In contrast, its downregulation in some other carcinoma is associated with disease progression, suggesting a tumor-suppressive role. These opposing functions underscore miR-362 involvement in complex regulatory networks and supports its potential as a biomarker for diagnosis, prognosis, and possibly therapeutic intervention. This review aims to provide an overview of the current understanding of miR-362 expression patterns, molecular targets, regulatory mechanisms, and its dual role in cancer biology, with the goal of clarifying its clinical significance in cancer diagnosis, prognosis, and therapy.

Graphical Abstract

The specific targets of miR-362 across various malignancies