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<p>Angiogenesis plays a critical role in cancer progression, highlighting the need for effective anti-angiogenic therapies. Zerumbone (ZER), a phytochemical compound, is known for its anti-angiogenic and anti-carcinogenic effects in various cancer cell lines. Cisplatin (CIS) is a widely used chemotherapeutic agent that effectively inhibits tumor growth. Combining CIS with anti-angiogenic agents like ZER may enhance the anticancer efficacy of CIS and improve treatment outcomes. This study aimed to evaluate the acute toxicity and anti-angiogenic effects of ZER, CIS, and the ZER + CIS combination in a zebrafish larval model. At higher concentrations, the ZER + CIS combination demonstrated only minimal toxicity. Both CIS and ZER exhibited significant anti-angiogenic activity, as indicated by the depletion of o-dianisidine-positive red blood cells in circulation compared to the control. The combination of ZER and CIS synergistically enhanced the down-regulation of VEGF-A (p &lt; 0.001), VEGFR-2, NRP-1A, and NRP-2B, confirming the synergistic action of the two compounds. In conclusion, the combination of ZER and CIS exhibited superior anti-angiogenic effects compared to either treatment alone, suggesting a promising therapeutic strategy for cancer treatment.</p> Graphical abstract <p></p>

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Evaluation of synergistic effect of Zerumbone with Cisplatin on anti-angiogenic potential in zebrafish model

  • 期刊论文

  • 发表日期：

    2025年6月11日

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  • Dayalan Haripriya,
  • Jegannathan Srimathi Devi,
  • Arul Santhosh,
  • Giridharan Bupesh,
  • Mayur Mausoom Phukan,
  • Jogeswar Panigrahi,
  • Chitta Ranjan Deb,
  • Manickam Mathyazhagan,
  • Dharmalingam Kirubakaran,
  • Konda Mani Saravanan,
  • Parasuraman Padmanabhan,
  • Domokos Mathe,
  • Govindaraju Archunan

摘要

Angiogenesis plays a critical role in cancer progression, highlighting the need for effective anti-angiogenic therapies. Zerumbone (ZER), a phytochemical compound, is known for its anti-angiogenic and anti-carcinogenic effects in various cancer cell lines. Cisplatin (CIS) is a widely used chemotherapeutic agent that effectively inhibits tumor growth. Combining CIS with anti-angiogenic agents like ZER may enhance the anticancer efficacy of CIS and improve treatment outcomes. This study aimed to evaluate the acute toxicity and anti-angiogenic effects of ZER, CIS, and the ZER + CIS combination in a zebrafish larval model. At higher concentrations, the ZER + CIS combination demonstrated only minimal toxicity. Both CIS and ZER exhibited significant anti-angiogenic activity, as indicated by the depletion of o-dianisidine-positive red blood cells in circulation compared to the control. The combination of ZER and CIS synergistically enhanced the down-regulation of VEGF-A (p < 0.001), VEGFR-2, NRP-1A, and NRP-2B, confirming the synergistic action of the two compounds. In conclusion, the combination of ZER and CIS exhibited superior anti-angiogenic effects compared to either treatment alone, suggesting a promising therapeutic strategy for cancer treatment.

Graphical abstract