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<p>This study investigated oxidative stress biomarkers in differentiating trichotillomania (TTM), obsessive–compulsive disorder (OCD), and healthy controls (HC), focusing on thiol-disulfide homeostasis, total oxidant status (TOS), total antioxidant status (TAS), and ischemia-modified albumin (IMA). A total of 68 adolescent females aged 10–18 were recruited and divided into three groups: TTM (n = 24), OCD (n = 21), and HC (n = 23). Oxidative stress biomarkers were assessed through blood analyses, including measurements of thiol-disulfide homeostasis, TOS, TAS, and IMA. Blood analyses revealed that TTM patients had significantly lower native and total thiol levels, a reduced native/total thiol ratio, and elevated disulfide levels compared to OCD and HC (p &lt; 0.01). ROC analysis indicated that the native thiol/total thiol ratio effectively distinguished TTM from both HC and OCD with high accuracy. These findings reveal distinct oxidative stress patterns in TTM and OCD, with disrupted thiol-disulfide homeostasis in TTM and elevated oxidative burden in OCD. The discriminative power of the native thiol/total thiol ratio suggests molecular-level differences, which may inform the etiopathogenesis of TTM and support the development of targeted treatment strategies.</p>

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Can Oxidative Stress Biomarkers Differentiate Trichotillomania from Obsessive–Compulsive Disorder and Healthy Controls?

  • 期刊论文

  • 发表日期：

    2025年10月2日

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  • Yusuf Selman Çelik,
  • Hande Günal Okumuş,
  • Meryem Kaşak,
  • Göktuğ Okyar,
  • Barışcan Çimen,
  • Yusuf Öztürk,
  • Ayşegül Efe,
  • Özcan Erel

摘要

This study investigated oxidative stress biomarkers in differentiating trichotillomania (TTM), obsessive–compulsive disorder (OCD), and healthy controls (HC), focusing on thiol-disulfide homeostasis, total oxidant status (TOS), total antioxidant status (TAS), and ischemia-modified albumin (IMA). A total of 68 adolescent females aged 10–18 were recruited and divided into three groups: TTM (n = 24), OCD (n = 21), and HC (n = 23). Oxidative stress biomarkers were assessed through blood analyses, including measurements of thiol-disulfide homeostasis, TOS, TAS, and IMA. Blood analyses revealed that TTM patients had significantly lower native and total thiol levels, a reduced native/total thiol ratio, and elevated disulfide levels compared to OCD and HC (p < 0.01). ROC analysis indicated that the native thiol/total thiol ratio effectively distinguished TTM from both HC and OCD with high accuracy. These findings reveal distinct oxidative stress patterns in TTM and OCD, with disrupted thiol-disulfide homeostasis in TTM and elevated oxidative burden in OCD. The discriminative power of the native thiol/total thiol ratio suggests molecular-level differences, which may inform the etiopathogenesis of TTM and support the development of targeted treatment strategies.