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<p>The objective of this study is to explore the association of common genetic variation of anxiety disorders and essential tremor (ET). We genotyped 25 anxiety-specific risk variants in a cohort of 478 unrelated ET patients and 504 age and gender-matched healthy controls from eastern China using a MassARRAY system. The association between candidate variants and ET patients was evaluated using gene-based analysis. A total of 159 patients (33.3%) had anxiety. In genotypic analysis, rs708012 (in an intergenic region) in the dominant models was found to be significantly associated with ET (<i>P</i> &lt; 0.001, OR = 0.605). In allelic analysis, the carriers of the C allele of <i>NTRK2</i> rs1187280 (<i>P</i> = 0.027, OR = 0.626), T allele of <i>TMEM106B</i> rs3807866 (<i>P</i> = 0.030, OR = 1.287), and T allele of rs708012 (<i>P</i> &lt; 0.001, OR = 0.679) occupy a larger proportion of ET patients compared with healthy controls. Anxiety-specific risk SNPs of <i>TMEM106B</i> rs3807866 increase the risk for ET, while two SNPs of <i>NTRK2</i> rs1187280 and rs708012 show a protective role.</p>

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Analysis of Common Genetic Variation of Anxiety Disorders in Essential Tremor

  • 期刊论文

  • 发表日期：

    2025年1月31日

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  • Yaping Yan,
  • Lanxiao Cao,
  • Luyan Gu,
  • Congying Xu,
  • Jinyu Lu,
  • Dayao Lv,
  • Jun Tian,
  • Xinzhen Yin,
  • Jiali Pu,
  • Baorong Zhang,
  • Guohua Zhao

摘要

The objective of this study is to explore the association of common genetic variation of anxiety disorders and essential tremor (ET). We genotyped 25 anxiety-specific risk variants in a cohort of 478 unrelated ET patients and 504 age and gender-matched healthy controls from eastern China using a MassARRAY system. The association between candidate variants and ET patients was evaluated using gene-based analysis. A total of 159 patients (33.3%) had anxiety. In genotypic analysis, rs708012 (in an intergenic region) in the dominant models was found to be significantly associated with ET (P < 0.001, OR = 0.605). In allelic analysis, the carriers of the C allele of NTRK2 rs1187280 (P = 0.027, OR = 0.626), T allele of TMEM106B rs3807866 (P = 0.030, OR = 1.287), and T allele of rs708012 (P < 0.001, OR = 0.679) occupy a larger proportion of ET patients compared with healthy controls. Anxiety-specific risk SNPs of TMEM106B rs3807866 increase the risk for ET, while two SNPs of NTRK2 rs1187280 and rs708012 show a protective role.