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Purpose <p>Patients undergoing cholecystectomy for a presumed benign disease may present with histopathology report revealing carcinoma in the gallbladder specimen, in which case it is referred to as incidental gallbladder cancer (IGBC). This review highlights the approach to evaluation and management of these patients.</p> Methods <p>Available literature from various sources has been reviewed and presented in a narrative format.</p> Results <p>Early referral to a tertiary centre for appropriate staging and definitive management is paramount. Once distant metastasis is ruled out, re-resection is indicated in patients with&#xa0;pathological T-stage ≥T1b with the aim to&#xa0;attain R0 resection, and perform complete staging lymphadenectomy, and&#xa0;has been shown to confer survival&#xa0;benefit. Feasibility and safety of minimally invasive approaches have been&#xa0;demonstrated in recent years. Role of&#xa0;peri-operative chemo(radio)-therapy in IGBC remains uncertain and&#xa0;prospective trials are warranted.</p> Conclusion <p>IGBC is being increasingly diagnosed as the number of cholecystectomies for presumed benign diseases is steadily increasing globally. Overall prognosis depends on the stage and is especially poor in those with residual disease at re-operation.</p>

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Incidental Gallbladder Cancer: A Comprehensive Review

  • 期刊论文

  • 发表日期：

    2025年4月5日

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  • Pritesh Kumar N,
  • Yashika Gupta,
  • Hirdaya H. Nag

摘要

Purpose

Patients undergoing cholecystectomy for a presumed benign disease may present with histopathology report revealing carcinoma in the gallbladder specimen, in which case it is referred to as incidental gallbladder cancer (IGBC). This review highlights the approach to evaluation and management of these patients.

Methods

Available literature from various sources has been reviewed and presented in a narrative format.

Results

Early referral to a tertiary centre for appropriate staging and definitive management is paramount. Once distant metastasis is ruled out, re-resection is indicated in patients with pathological T-stage ≥T1b with the aim to attain R0 resection, and perform complete staging lymphadenectomy, and has been shown to confer survival benefit. Feasibility and safety of minimally invasive approaches have been demonstrated in recent years. Role of peri-operative chemo(radio)-therapy in IGBC remains uncertain and prospective trials are warranted.

Conclusion

IGBC is being increasingly diagnosed as the number of cholecystectomies for presumed benign diseases is steadily increasing globally. Overall prognosis depends on the stage and is especially poor in those with residual disease at re-operation.