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Background <p>Pulse shape index (PSI) is a novel artificial intelligence–supported parameter that evaluates the pressure–volume compensatory reserve of the craniospinal system through intracranial pressure (ICP) pulse waveform classification. This study assessed the agreement between PSI derived from invasive ICP monitoring (PSI<sub>ICP</sub>) and noninvasive brain4care (B4C) sensor signal (PSI<sub>B4C</sub>) and investigated the influence of cranial integrity, age, and internal jugular vein (IJV) compression on PSI values.</p> Methods <p>Simultaneous ICP and B4C monitoring was performed in 47 adult patients ( age: 43&#xa0;(30) years) before and during IJV compression. Patients were grouped by cranial integrity: intact skull bone (<i>n</i> = 17), large skull fractures or craniotomies (<i>n</i> = 17), and craniectomies (<i>n</i> = 13). Pulse waveforms were automatically classified into four classes (from 1 = normal to 4 = pathological) by a neural network, and PSI was calculated as the weighted average of class numbers.&#xa0;Values are presented as median (interquartile range).</p> Results <p>Bland–Altman analysis demonstrated good agreement between PSI<sub>ICP</sub> and PSI<sub>B4C</sub>, with approximately 6% outliers. PSI was significantly higher in patients who underwent craniectomy compared with those with intact skulls (PSI<sub>ICP</sub>:&#xa0;3.5 (0.8) vs. 2.0 (1.2) arbitrary units, <i>p</i> &lt; 0.002; PSI<sub>B4C</sub>:&#xa0;3.0 (0.4) vs. 2.0 (0.6) arbitrary units, <i>p</i> &lt; 0.005) or those with craniotomies or large fractures (PSI<sub>ICP</sub>:&#xa0;3.5 (0.8) vs. 2.0 (2.1) arbitrary units, <i>p</i> &lt; 0.05; PSI<sub>B4C</sub>:&#xa0;3.0 (0.4) vs. 2.0 (2.2) arbitrary units, <i>p</i> &lt; 0.05). IJV compression did not affect PSI. Both PSI<sub>ICP</sub> (r<sub>s</sub> = 0.35, <i>p</i> &lt; 0.02) and PSI<sub>B4C</sub> (r<sub>s</sub> = 0.37, <i>p</i> = 0.01) correlated with age.</p> Conclusions <p>This study supports the B4C signal’s capability to noninvasively reflect ICP waveform morphology via PSI, offering a promising monitoring alternative. PSI appears to be influenced by age and craniectomy but not by a slight, sudden ICP change induced by IJV compression.</p>

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Invasive and Noninvasive Intracranial Pressure Pulse Waveform in Neurocritical Care Patients with Different Cranium Integrity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月1日

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  • Magdalena Kasprowicz,
  • Agnieszka Kazimierska,
  • Marta Hendler,
  • Danilo Cardim,
  • Zofia Czosnyka,
  • Marek Czosnyka,
  • Wellingson Paiva,
  • Sergio Brasil

摘要

Background

Pulse shape index (PSI) is a novel artificial intelligence–supported parameter that evaluates the pressure–volume compensatory reserve of the craniospinal system through intracranial pressure (ICP) pulse waveform classification. This study assessed the agreement between PSI derived from invasive ICP monitoring (PSIICP) and noninvasive brain4care (B4C) sensor signal (PSIB4C) and investigated the influence of cranial integrity, age, and internal jugular vein (IJV) compression on PSI values.

Methods

Simultaneous ICP and B4C monitoring was performed in 47 adult patients ( age: 43 (30) years) before and during IJV compression. Patients were grouped by cranial integrity: intact skull bone (n = 17), large skull fractures or craniotomies (n = 17), and craniectomies (n = 13). Pulse waveforms were automatically classified into four classes (from 1 = normal to 4 = pathological) by a neural network, and PSI was calculated as the weighted average of class numbers. Values are presented as median (interquartile range).

Results

Bland–Altman analysis demonstrated good agreement between PSIICP and PSIB4C, with approximately 6% outliers. PSI was significantly higher in patients who underwent craniectomy compared with those with intact skulls (PSIICP: 3.5 (0.8) vs. 2.0 (1.2) arbitrary units, p < 0.002; PSIB4C: 3.0 (0.4) vs. 2.0 (0.6) arbitrary units, p < 0.005) or those with craniotomies or large fractures (PSIICP: 3.5 (0.8) vs. 2.0 (2.1) arbitrary units, p < 0.05; PSIB4C: 3.0 (0.4) vs. 2.0 (2.2) arbitrary units, p < 0.05). IJV compression did not affect PSI. Both PSIICP (rs = 0.35, p < 0.02) and PSIB4C (rs = 0.37, p = 0.01) correlated with age.

Conclusions

This study supports the B4C signal’s capability to noninvasively reflect ICP waveform morphology via PSI, offering a promising monitoring alternative. PSI appears to be influenced by age and craniectomy but not by a slight, sudden ICP change induced by IJV compression.