<p>Traumatic brain injury (TBI) is a significant global health issue, yet its impact is disproportionately borne by low-income and middle-income countries (LMICs), where higher exposure to risk factors and limited health care resources exacerbate the burden. Despite this, the majority of TBI research is derived from data sets curated in high-income countries (HICs), where research infrastructure and resources are more extensive. As a result, clinical guidelines for TBI management are primarily shaped by data from HICs, with little consideration for the distinct factors and health care challenges in resource-limited settings. This gap hinders the development of effective TBI management guidelines for LMICs, where unique circumstances and challenges such as injury mechanisms, prehospital care, comorbidities, and hospital resources must be considered. Nonetheless, HICs have the resources and infrastructure to collect data on variables that may not be as urgent in their own settings but are critical for understanding challenges in LMICs. Integrating these globally applicable variables into data sets from HICs is essential for facilitating more relevant cross-contextual comparisons and improving care in LMICs. Bridging this gap requires equitable collaboration with LMIC researchers to ensure their perspectives are prioritized and that research efforts contribute to the development of truly representative data sets. By fostering such collaborations, the global community can work toward evidence-based guidelines that reflect the diverse realities of TBI care, ultimately improving outcomes for patients worldwide.</p>