Scholarlink

<p>Snakebites constitute a significant global public health concern. Based on various toxic components and action mechanisms, snake venoms are typically classified into hemotoxic, neurotoxic, and histotoxic types. The pathological changes caused by different toxicities vary, which is often one of the key points in the forensic identification of snake bites. However, relying solely on this aspect often has certain limitations in the identification of snake bite cases, with poor qualitative and quantitative results. This article presents a case of identifying death caused by an <i>Agkistrodon halys</i> bite through the combined application of ELISA and immunohistochemistry (IHC) methods. The concentration of snake venom in the subcutaneous tissue at the fang marks was precisely measured at 6.58 ng/mL. In addition, we summarized the forensic characteristics of such snake venom poisoning by a retrospective analysis of the literature, aiming to provide reference for the forensic identification.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Forensic identification of Agkistrodon halys bite by the combination of ELISA and immunohistochemistry: a case report and literature review

  • 期刊论文

  • 发表日期：

    2026年2月4日

查看全文
  • Yubei Wang,
  • Zhaoxuan Wang,
  • Xiangting Gao,
  • Qing Shi,
  • Yuhao Yuan,
  • Chen Chen,
  • Zhonghao Yu,
  • Yiwu Zhou

摘要

Snakebites constitute a significant global public health concern. Based on various toxic components and action mechanisms, snake venoms are typically classified into hemotoxic, neurotoxic, and histotoxic types. The pathological changes caused by different toxicities vary, which is often one of the key points in the forensic identification of snake bites. However, relying solely on this aspect often has certain limitations in the identification of snake bite cases, with poor qualitative and quantitative results. This article presents a case of identifying death caused by an Agkistrodon halys bite through the combined application of ELISA and immunohistochemistry (IHC) methods. The concentration of snake venom in the subcutaneous tissue at the fang marks was precisely measured at 6.58 ng/mL. In addition, we summarized the forensic characteristics of such snake venom poisoning by a retrospective analysis of the literature, aiming to provide reference for the forensic identification.