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Purpose <p>To investigate the possibility that Pasireotide (PAS), which is a synthetic somatostatin analog (SSA), induces proteins related to autophagy in cancer cells.</p> Methods <p>MDA-MB-468 and HeLa human cancer cells were exposed to PAS or vehicle for 8, 24 and 32&#xa0;h, to assess possible effects in autophagy-related proteins. Western blot analysis was utilized to assess changes in protein expression levels due to PAS exposure.</p> Results <p>PAS treatment induces the expression of the autophagy-related protein (ATG)-3, ATG-7, and Beclin-1 in MDA-MB-468 and HeLa cells.</p> Conclusions <p>Our findings suggest that the beneficial effects of PAS in cancers may involve autophagy. Further studies will attempt to elucidate the underlying mechanisms mediating those effects.</p>

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Pasireotide induces proteins related to autophagy in cancer cells

  • 期刊论文

  • 发表日期：

    2026年7月10日

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  • Madan Sigdel,
  • Saikat Fakir,
  • Md Matiur Rahman Sarker,
  • Nektarios Barabutis

摘要

Purpose

To investigate the possibility that Pasireotide (PAS), which is a synthetic somatostatin analog (SSA), induces proteins related to autophagy in cancer cells.

Methods

MDA-MB-468 and HeLa human cancer cells were exposed to PAS or vehicle for 8, 24 and 32 h, to assess possible effects in autophagy-related proteins. Western blot analysis was utilized to assess changes in protein expression levels due to PAS exposure.

Results

PAS treatment induces the expression of the autophagy-related protein (ATG)-3, ATG-7, and Beclin-1 in MDA-MB-468 and HeLa cells.

Conclusions

Our findings suggest that the beneficial effects of PAS in cancers may involve autophagy. Further studies will attempt to elucidate the underlying mechanisms mediating those effects.