Scholarlink

Purpose <p>Non-diagnostic (ND) result of ultrasound-guided fine-needle aspiration cytology (FNAC) of thyroid nodules can lead to diagnostic delays, repeated procedures and, potentially, unnecessary surgeries. This study aimed to evaluate the role of patient age and gender as predictors of a ND cytological result of FNAC, both at first sampling and after repeat procedures.</p> Methods <p>We retrospectively analyzed 5,774 FNACs performed between October 2017 and April 2025 at a single tertiary center. All procedures were conducted by an experienced endocrinologist and interpreted by a single expert cytopathologist. ND rates were compared by age and gender. Logistic regression assessed independent associations, and interaction analysis evaluated whether age effects differed by gender.</p> Results <p>ND cytology occurred in 29.5% of cases. Patients with ND results were older (59.3 ± 14.2 vs. 57.3 ± 14.0 years, <i>p</i> &lt; 0.001) and more often male (29.6% vs. 23.0%, <i>p</i> &lt; 0.001). Logistic regression confirmed male gender (OR 1.376, 95% CI 1.211–1.563) and age (OR 1.009, 95% CI 1.005–1.013) as independent predictors (<i>p</i> &lt; 0.001 for both), with a significant age × gender interaction (<i>p</i> = 0.036), showing a stronger age effect in males. Among 443 patients repeating FNAC after an initial ND result, 39% remained ND, with no significant age or gender differences between persistent-ND and diagnostic outcomes.</p> Conclusion <p>Elderly age and male gender independently increase the likelihood of ND FNAC results. These factors should be considered when planning thyroid FNAC, although they do not predict persistent ND outcomes upon repeat sampling.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Elderly age and male gender as risk factors for Non Diagnostic cytology at thyroid fine needle aspiration: results of a large cytological series

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月9日

查看全文
  • Laura Croce,
  • Spyridon Chytiris,
  • Marsida Teliti,
  • Isabella Chiardi,
  • Francesca Coperchini,
  • Linda Loretta Businaro,
  • Flavia Magri,
  • Tshering Dorji,
  • Mario Rotondi

摘要

Purpose

Non-diagnostic (ND) result of ultrasound-guided fine-needle aspiration cytology (FNAC) of thyroid nodules can lead to diagnostic delays, repeated procedures and, potentially, unnecessary surgeries. This study aimed to evaluate the role of patient age and gender as predictors of a ND cytological result of FNAC, both at first sampling and after repeat procedures.

Methods

We retrospectively analyzed 5,774 FNACs performed between October 2017 and April 2025 at a single tertiary center. All procedures were conducted by an experienced endocrinologist and interpreted by a single expert cytopathologist. ND rates were compared by age and gender. Logistic regression assessed independent associations, and interaction analysis evaluated whether age effects differed by gender.

Results

ND cytology occurred in 29.5% of cases. Patients with ND results were older (59.3 ± 14.2 vs. 57.3 ± 14.0 years, p < 0.001) and more often male (29.6% vs. 23.0%, p < 0.001). Logistic regression confirmed male gender (OR 1.376, 95% CI 1.211–1.563) and age (OR 1.009, 95% CI 1.005–1.013) as independent predictors (p < 0.001 for both), with a significant age × gender interaction (p = 0.036), showing a stronger age effect in males. Among 443 patients repeating FNAC after an initial ND result, 39% remained ND, with no significant age or gender differences between persistent-ND and diagnostic outcomes.

Conclusion

Elderly age and male gender independently increase the likelihood of ND FNAC results. These factors should be considered when planning thyroid FNAC, although they do not predict persistent ND outcomes upon repeat sampling.