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Purpose <p>The association between estimated glucose disposal rate (eGDR) and prehypertension (pre-HTN) in non-diabetic Japanese adults was investigated in our study.</p> Methods <p>Data from 15,464 participants aged 18–79 years in the NAGALA-based study (2004–2015) were further analyzed. A total of 14,170 non-diabetic individuals were included to explore the association between eGDR—calculated using two established formulas, one based on waist circumference (WC) and the other on body mass index (BMI)—and pre-HTN. Multivariable logistic regression adjusted for serum biomarkers and clinical characteristics was used to evaluate the relationship. Both stratified analysis and Bayesian network (BN) models have been employed to further substantiate this relationship.</p> Results <p>30.1% of pre-HTN were shown in the enrolled patients (4,266/14,170). After adjusting for confounders, lower eGDR levels were significantly associated with higher pre-HTN risk. The adjusted odds ratio for the first tertile of eGDR.<sub>WC</sub> and eGDR.<sub>BMI</sub>, compared to the highest tertile, were 3.36 (95%CI: 2.99–3.77) and 3.39 (95%CI: 3.04–3.78) respectively. An increase of 1-unit in eGDR was found to link with a 52% reduction in the prevalence of pre-HTN for eGDR.<sub>WC</sub> (adjusted OR = 0.48, 95%CI: 0.45–0.51) and a 60% reduction for eGDR.<sub>BMI</sub> (adjusted OR = 0.40, 95%CI: 0.38–0.43). Stratified analysis confirmed a negative correlation between eGDR and pre-HTN across subgroups, which was also corroborated in BN models.</p> Conclusions <p>In non-diabetic Japanese adults, lower eGDR levels were significantly associated with higher pre-HTN prevalence, suggesting eGDR as a potential indicator for hypertension prevention and deserving more clinical research’s validation.</p>

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Estimated glucose disposal rate (eGDR) and prehypertension in Non-Diabetic Japanese adults: A secondary analysis of the NAGALA Cross-Sectional study

  • 期刊论文

  • 发表日期：

    2025年12月29日

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  • Dexi Wu,
  • Qinqin Wang,
  • Feng Wen,
  • Yasha Chen,
  • Hui Chen,
  • Yue Wu,
  • Zhiqing He,
  • Chun Liang

摘要

Purpose

The association between estimated glucose disposal rate (eGDR) and prehypertension (pre-HTN) in non-diabetic Japanese adults was investigated in our study.

Methods

Data from 15,464 participants aged 18–79 years in the NAGALA-based study (2004–2015) were further analyzed. A total of 14,170 non-diabetic individuals were included to explore the association between eGDR—calculated using two established formulas, one based on waist circumference (WC) and the other on body mass index (BMI)—and pre-HTN. Multivariable logistic regression adjusted for serum biomarkers and clinical characteristics was used to evaluate the relationship. Both stratified analysis and Bayesian network (BN) models have been employed to further substantiate this relationship.

Results

30.1% of pre-HTN were shown in the enrolled patients (4,266/14,170). After adjusting for confounders, lower eGDR levels were significantly associated with higher pre-HTN risk. The adjusted odds ratio for the first tertile of eGDR.WC and eGDR.BMI, compared to the highest tertile, were 3.36 (95%CI: 2.99–3.77) and 3.39 (95%CI: 3.04–3.78) respectively. An increase of 1-unit in eGDR was found to link with a 52% reduction in the prevalence of pre-HTN for eGDR.WC (adjusted OR = 0.48, 95%CI: 0.45–0.51) and a 60% reduction for eGDR.BMI (adjusted OR = 0.40, 95%CI: 0.38–0.43). Stratified analysis confirmed a negative correlation between eGDR and pre-HTN across subgroups, which was also corroborated in BN models.

Conclusions

In non-diabetic Japanese adults, lower eGDR levels were significantly associated with higher pre-HTN prevalence, suggesting eGDR as a potential indicator for hypertension prevention and deserving more clinical research’s validation.