Scholarlink

Purpose <p>The incidence of inflammatory bowel diseases (IBDs) and gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) has increased, but their potential association remains unclear. Chronic inflammation in IBD may contribute to enteroendocrine cell hyperplasia and neoplasia, though evidence for a causal link is limited. This case series describes the characteristics and outcomes of patients with coexisting IBD and GEP-NETs at a tertiary referral center.</p> Methods <p>Retrospective case series including all consecutive IBD patients who were referred to the IBD Unit at the IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy, between January 2019 and December 2024 and who had been diagnosed with a GEP-NET.</p> Results <p>Nine Crohn’s disease patients (44.4% female, mean IBD diagnosis age: 51.1 years) also had GEP-NETs. The median interval between IBD and GEP-NET diagnoses was 39.3 months (0-180). In the totality of six cases that underwent surgical intervention, NETs diagnosis was incidental on the surgical specimen. Lesion sites included ileum (3), appendix (3), stomach (2), and rectum (1). Most NETs were G1 (88.8%); one required somatostatin analogues due to metastases. Treatments included surgery (6), endoscopy (2), and one pending. Over a median 24-month follow-up, no recurrences or disease-related deaths occurred. No cases of ulcerative colitis and concomitant GEP-NET ‘s diagnosis were observed in the patient cohort under consideration.</p> Conclusions <p>Patients with Crohn’s disease may have a higher prevalence of GEP-NETs, possibly due to chronic inflammation and immune/microbiota dysregulation. This association does not appear to worsen disease outcomes. Larger studies are needed to explore underlying mechanisms.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Neuroendocrine tumors in patients with inflammatory bowel disease: a case series

  • 期刊论文

  • 发表日期：

    2025年10月15日

查看全文
  • Roberta Elisa Rossi,
  • Benedetta Masoni,
  • Giulia Migliorisi,
  • Cristina Bezzio,
  • Alexia Francesca Bertuzzi,
  • Silvia Uccella,
  • Andrea Gerardo Antonio Lania,
  • Alessandro Zerbi,
  • Antonino Spinelli,
  • Cesare Hassan,
  • Alessandro Repici,
  • Alessandro Armuzzi

摘要

Purpose

The incidence of inflammatory bowel diseases (IBDs) and gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) has increased, but their potential association remains unclear. Chronic inflammation in IBD may contribute to enteroendocrine cell hyperplasia and neoplasia, though evidence for a causal link is limited. This case series describes the characteristics and outcomes of patients with coexisting IBD and GEP-NETs at a tertiary referral center.

Methods

Retrospective case series including all consecutive IBD patients who were referred to the IBD Unit at the IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy, between January 2019 and December 2024 and who had been diagnosed with a GEP-NET.

Results

Nine Crohn’s disease patients (44.4% female, mean IBD diagnosis age: 51.1 years) also had GEP-NETs. The median interval between IBD and GEP-NET diagnoses was 39.3 months (0-180). In the totality of six cases that underwent surgical intervention, NETs diagnosis was incidental on the surgical specimen. Lesion sites included ileum (3), appendix (3), stomach (2), and rectum (1). Most NETs were G1 (88.8%); one required somatostatin analogues due to metastases. Treatments included surgery (6), endoscopy (2), and one pending. Over a median 24-month follow-up, no recurrences or disease-related deaths occurred. No cases of ulcerative colitis and concomitant GEP-NET ‘s diagnosis were observed in the patient cohort under consideration.

Conclusions

Patients with Crohn’s disease may have a higher prevalence of GEP-NETs, possibly due to chronic inflammation and immune/microbiota dysregulation. This association does not appear to worsen disease outcomes. Larger studies are needed to explore underlying mechanisms.