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Purpose <p>Our study aimed to analyze the impact of renal function, assessed by various methods of evaluating glomerular filtration rate (GFR), on glycated hemoglobin A1c (HbA1c), glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG).</p> Methods <p>This cross-sectional study analyzed 5113 type 2 diabetes patients. GFR was evaluated using both <sup>99m</sup>Tc-DTPA dynamic renal scintigraphy (mGFR) and various estimating equations, including eGFRcr, eGFRcys, eGFRcr-cys, and eGFRc_MDRD.</p> Results <p>Overall, the median or mean values of HbA1c, GA, serum 1,5-AG, and mGFR were 8.3 (7.2–9.8)%, 21.0 (17.5–25.9)%, 3.4 (1.8–7.1) μg/mL, and 88.3 ± 24.1 mL/min/1.73 m<sup>2</sup>, respectively. Multiple linear regression demonstrated that HbA1c and GA were not correlated with mGFR (both <i>P</i> &gt; 0.05), but showed weak associations in all equations besides eGFRcys (β = 0.002–0.008, all <i>P</i> &lt; 0.001). Serum 1,5-AG correlated mildly with all GFR measures (β = −0.016 to −0.048, all <i>P</i> &lt; 0.001). When FPG and 2hPG were used as references for “actual” glucose level, significant and moderate associations were observed between HbA1c and GA with FPG (<i>r</i> = 0.324–0.649, all <i>P</i> &lt; 0.001) and 2hPG (<i>r</i> = 0.341–0.592, all <i>P</i> &lt; 0.001) across all CKD categories. Serum 1,5-AG maintained negative correlations with FPG and 2hPG (<i>r</i> = −0.239 to −0.463, all <i>P</i> &lt; 0.001) in GFR ≥ 30 mL/min/1.73 m<sup>2</sup>, but not in GFR &lt; 30 mL/min/1.73 m<sup>2</sup>. Results were consistent across all assessments using both mGFR and eGFR derived from the four equations.</p> Conclusion <p>In subjects with mild-to-moderate renal insufficiency, HbA1c, GA, and serum 1,5-AG are reliable indicators of glucose control.</p>

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Association between glycemic control indicators with renal function assessed by 99mTc-DTPA dynamic renal scintigraphy and estimating equations

  • 期刊论文

  • 发表日期：

    2025年6月4日

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  • Hang Su,
  • Jiaying Ni,
  • Danfeng Peng,
  • Xingxing He,
  • Wei Lu,
  • Wei Zhu,
  • Yufei Wang,
  • Xiaojing Ma,
  • Jingyi Lu,
  • Jian Zhou

摘要

Purpose

Our study aimed to analyze the impact of renal function, assessed by various methods of evaluating glomerular filtration rate (GFR), on glycated hemoglobin A1c (HbA1c), glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG).

Methods

This cross-sectional study analyzed 5113 type 2 diabetes patients. GFR was evaluated using both 99mTc-DTPA dynamic renal scintigraphy (mGFR) and various estimating equations, including eGFRcr, eGFRcys, eGFRcr-cys, and eGFRc_MDRD.

Results

Overall, the median or mean values of HbA1c, GA, serum 1,5-AG, and mGFR were 8.3 (7.2–9.8)%, 21.0 (17.5–25.9)%, 3.4 (1.8–7.1) μg/mL, and 88.3 ± 24.1 mL/min/1.73 m2, respectively. Multiple linear regression demonstrated that HbA1c and GA were not correlated with mGFR (both P > 0.05), but showed weak associations in all equations besides eGFRcys (β = 0.002–0.008, all P < 0.001). Serum 1,5-AG correlated mildly with all GFR measures (β = −0.016 to −0.048, all P < 0.001). When FPG and 2hPG were used as references for “actual” glucose level, significant and moderate associations were observed between HbA1c and GA with FPG (r = 0.324–0.649, all P < 0.001) and 2hPG (r = 0.341–0.592, all P < 0.001) across all CKD categories. Serum 1,5-AG maintained negative correlations with FPG and 2hPG (r = −0.239 to −0.463, all P < 0.001) in GFR ≥ 30 mL/min/1.73 m2, but not in GFR < 30 mL/min/1.73 m2. Results were consistent across all assessments using both mGFR and eGFR derived from the four equations.

Conclusion

In subjects with mild-to-moderate renal insufficiency, HbA1c, GA, and serum 1,5-AG are reliable indicators of glucose control.