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<p>Iron deficiency (ID) is a leading nutritional disorder in children, progressing from early iron deficiency (EID) to iron deficiency anemia (IDA). Hepcidin-25 is the key regulator of iron metabolism. This study aimed to evaluate the diagnostic value of hepcidin-25 and its association with hematological, biochemical, and antioxidant markers. Ninety children aged 2–10 years were enrolled and categorized into three groups: control, early iron deficiency (EID), and iron deficiency anemia (IDA) (n = 30 each). Blood samples were collected and analyzed for hematological parameters, iron profile, and C-reactive protein (CRP). In addition, catalase (CAT) activity was measured as an antioxidant marker, and serum hepcidin-25 levels were determined using an enzyme-linked immunosorbent assay (ELISA). Hepcidin-25 concentrations and CAT activity were significantly reduced in both EID and IDA groups compared with controls (p &lt; 0.05). Hepcidin-25 correlated positively with serum iron, transferrin saturation, ferritin, and CAT, and negatively with red cell distribution width (RDW), CRP, and total iron-binding capacity (TIBC). Receiver operating characteristic (ROC) analysis showed that hepcidin-25 had a more favorable diagnostic performance compared to ferritin for detecting IDA (AUC = 0.82) and EID (AUC = 0.73). Serum hepcidin-25 appears to be a promising biomarker for the early detection of pediatric iron deficiency and may also reflect alterations related to oxidative stress.</p>

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Hepcidin-25 as a Diagnostic and Oxidative Stress-Linked Biomarker in Pediatric with Early Iron Deficiency

  • 期刊论文

  • 发表日期：

    2025年10月22日

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  • Mhabad Khorsheed Saeed,
  • Lina Yousif Mohammed

摘要

Iron deficiency (ID) is a leading nutritional disorder in children, progressing from early iron deficiency (EID) to iron deficiency anemia (IDA). Hepcidin-25 is the key regulator of iron metabolism. This study aimed to evaluate the diagnostic value of hepcidin-25 and its association with hematological, biochemical, and antioxidant markers. Ninety children aged 2–10 years were enrolled and categorized into three groups: control, early iron deficiency (EID), and iron deficiency anemia (IDA) (n = 30 each). Blood samples were collected and analyzed for hematological parameters, iron profile, and C-reactive protein (CRP). In addition, catalase (CAT) activity was measured as an antioxidant marker, and serum hepcidin-25 levels were determined using an enzyme-linked immunosorbent assay (ELISA). Hepcidin-25 concentrations and CAT activity were significantly reduced in both EID and IDA groups compared with controls (p < 0.05). Hepcidin-25 correlated positively with serum iron, transferrin saturation, ferritin, and CAT, and negatively with red cell distribution width (RDW), CRP, and total iron-binding capacity (TIBC). Receiver operating characteristic (ROC) analysis showed that hepcidin-25 had a more favorable diagnostic performance compared to ferritin for detecting IDA (AUC = 0.82) and EID (AUC = 0.73). Serum hepcidin-25 appears to be a promising biomarker for the early detection of pediatric iron deficiency and may also reflect alterations related to oxidative stress.