<p>Periodontal diseases are common inflammatory conditions that affect tissues supporting the teeth, including the gingiva, bone, and ligaments. If left untreated, they can lead to tooth loss and have been linked to more severe systemic inflammation. Saliva, which contains a variety of biological substances, provides a non-invasive method for studying oral and general health. Hyperlipidemia, a condition marked by high levels of cholesterol, triglycerides, and LDL, along with low HDL, is associated with cardiovascular disease. Malondialdehyde (MDA), a byproduct of lipid peroxidation, is often used as a marker of oxidative stress. Lipopolysaccharides (LPS), which are bacterial toxins, also play a role in the development of periodontitis. The aim of the study explores the link between salivary lipid levels and periodontitis and investigates whether MDA levels in saliva could reflect disease presence. Forty individuals took part in this study. Twenty had healthy gingiva, while the other twenty were diagnosed with periodontitis. Each participant underwent a full periodontal checkup, including measures like plaque and gingival indices, bleeding on probing, pocket depth, and attachment loss. Saliva samples were collected to measure lipid profiles and MDA levels. Those with periodontitis had significantly higher levels of total cholesterol, triglycerides, LDL, and MDA in their saliva. HDL was lower compared to the healthy group. The findings suggest a possible connection between high lipid levels and gingiva disease. MDA may be a useful marker for oxidative stress in people with periodontitis.</p>