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<p>Interleukin 6 (<i>IL6</i>) is an inflammatory biomarker linked to central and peripheral nervous system diseases. This study combined bioinformatics and statistical meta-analysis to explore potential associations between <i>IL6</i> gene variants (rs1800795, rs1800796, and rs1800797) and neurological disorders (NDs) and brain cancer. The meta-analysis was conducted on substantial case–control datasets and revealed a significant correlation between <i>IL6</i> SNPs (rs1800795 and rs1800796) with overall NDs (<i>p</i>-value &lt; 0.05). The disease-stratified analysis of rs1800795 revealed significant correlations with Schizophrenia, Alzheimer’s, and Parkinson’s diseases (<i>p</i>-value &lt; 0.05), while rs1800796 showed a substantial connection with Celiac disease (<i>p</i>-value &lt; 0.05). The ethnicity-stratified analysis revealed noteworthy associations between rs1800795 in both Asians and Caucasians (<i>p</i>-value &lt; 0.05), while rs1800796 showed significant associations across all ethnic groups analyzed (<i>p</i>-value &lt; 0.05). Furthermore, integrated Bioinformatics analyses using GTEx and TCGA datasets highlighted <i>IL6</i>’s involvement in NDs and its potential role in brain cancer. Specifically, <i>IL6</i> SNPs (rs1800795 and rs1800797) showed a significant association with Glioma (<i>p</i>-value &lt; 0.001). Copy number alterations and increased <i>IL6</i> expressions were linked to cancer severity (<i>p</i>-value &lt; 0.001) and hypoxia (<i>p</i>-value &lt; 0.0001). Kaplan–Meier survival analysis demonstrated that elevated <i>IL6</i> expression was strongly associated with decreased overall survival in brain cancer patients (<i>p</i>-value &lt; 0.0001). In conclusion, this study identified notable correlations between <i>IL6</i> SNPs and NDs, underscoring their potential as valuable prognostic biomarkers for various neurological conditions.</p>

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Association of IL6 Gene Polymorphisms and Neurological Disorders: Insights from Integrated Bioinformatics and Meta-Analysis

  • 期刊论文

  • 发表日期：

    2025年1月15日

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  • Md. Harun-Or-Roshid,
  • Md. Nurul Haque Mollah,
  • Jesmin

摘要

Interleukin 6 (IL6) is an inflammatory biomarker linked to central and peripheral nervous system diseases. This study combined bioinformatics and statistical meta-analysis to explore potential associations between IL6 gene variants (rs1800795, rs1800796, and rs1800797) and neurological disorders (NDs) and brain cancer. The meta-analysis was conducted on substantial case–control datasets and revealed a significant correlation between IL6 SNPs (rs1800795 and rs1800796) with overall NDs (p-value < 0.05). The disease-stratified analysis of rs1800795 revealed significant correlations with Schizophrenia, Alzheimer’s, and Parkinson’s diseases (p-value < 0.05), while rs1800796 showed a substantial connection with Celiac disease (p-value < 0.05). The ethnicity-stratified analysis revealed noteworthy associations between rs1800795 in both Asians and Caucasians (p-value < 0.05), while rs1800796 showed significant associations across all ethnic groups analyzed (p-value < 0.05). Furthermore, integrated Bioinformatics analyses using GTEx and TCGA datasets highlighted IL6’s involvement in NDs and its potential role in brain cancer. Specifically, IL6 SNPs (rs1800795 and rs1800797) showed a significant association with Glioma (p-value < 0.001). Copy number alterations and increased IL6 expressions were linked to cancer severity (p-value < 0.001) and hypoxia (p-value < 0.0001). Kaplan–Meier survival analysis demonstrated that elevated IL6 expression was strongly associated with decreased overall survival in brain cancer patients (p-value < 0.0001). In conclusion, this study identified notable correlations between IL6 SNPs and NDs, underscoring their potential as valuable prognostic biomarkers for various neurological conditions.