Scholarlink

<p>Airway remodeling, a hallmark of asthma, involves structural and functional changes in the airways including extracellular matrix (ECM) deposition, airway smooth muscle (ASM) cell hypertrophy and hyperplasia, epithelial and fibroblasts remodeling, and mitochondrial dysfunction driven by chronic inflammation. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor commonly known for mediating xenobiotic responses, has recently emerged as a key regulator of cellular processes implicated in airway remodeling. This review explores the multifaceted role of AhR in modulating proliferation, migration, ECM remodeling, contraction, and mitochondrial homeostasis across various airway structural cell types. Based on recent studies, we highlight how AhR exerts anti-proliferative effects in ASM, epithelial, and fibroblasts, modulates calcium signaling to influence contraction, and regulates ECM turnover via transforming growth factor-β and matrix metallopeptidase pathways. Additionally, the dual, ligand- and context-dependent nature of AhR activation is emphasized, with both protective and detrimental outcomes observed depending on the specific agonist and disease conditions. Collectively, this review underscores the therapeutic potential of targeting AhR in airway remodeling.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Role of Aryl Hydrocarbon Receptor in Airway Remodeling: Mechanistic Insights Across Cellular Functions

  • 期刊论文

  • 发表日期：

    2026年2月9日

查看全文
  • Mohammad Irshad Reza,
  • Ashish Kumar,
  • Rodney D. Britt Jr.,
  • Venkatachalem Sathish

摘要

Airway remodeling, a hallmark of asthma, involves structural and functional changes in the airways including extracellular matrix (ECM) deposition, airway smooth muscle (ASM) cell hypertrophy and hyperplasia, epithelial and fibroblasts remodeling, and mitochondrial dysfunction driven by chronic inflammation. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor commonly known for mediating xenobiotic responses, has recently emerged as a key regulator of cellular processes implicated in airway remodeling. This review explores the multifaceted role of AhR in modulating proliferation, migration, ECM remodeling, contraction, and mitochondrial homeostasis across various airway structural cell types. Based on recent studies, we highlight how AhR exerts anti-proliferative effects in ASM, epithelial, and fibroblasts, modulates calcium signaling to influence contraction, and regulates ECM turnover via transforming growth factor-β and matrix metallopeptidase pathways. Additionally, the dual, ligand- and context-dependent nature of AhR activation is emphasized, with both protective and detrimental outcomes observed depending on the specific agonist and disease conditions. Collectively, this review underscores the therapeutic potential of targeting AhR in airway remodeling.