Scholarlink

<p>In this study, Zn- and Cu-based nanoflowers were synthesized using <i>Rheum tataricum</i> L. root extract through a green and eco-friendly approach. The nanostructures were preliminarily characterized using SEM, FTIR, XRD, and EDX analyses. Subsequently, their biological activities were comprehensively evaluated, including antioxidant potential (DPPH and ABTS assays), acetylcholinesterase (AChE) inhibitory properties, cytotoxic effects on A549 lung cancer cells, and antimicrobial as well as antibiofilm activities against clinically relevant pathogenic bacteria with different resistance profiles. RT@Cu-hNFs exhibited IC₅₀ values of 221&#xa0;µg/mL (DPPH) and 146&#xa0;µg/mL (ABTS), whereas RT@Zn-hNFs showed stronger antioxidant activity with IC₅₀ values of 62.7&#xa0;µg/mL and 4.7&#xa0;µg/mL, respectively. The AChE inhibitory IC₅₀ values were 53&#xa0;µg/mL for RT@Cu-hNFs and 29.6&#xa0;µg/mL for RT@Zn-hNFs, indicating a higher enzyme inhibitory potential for the Zn-based nanoflowers. Cytotoxicity assays revealed that RT@Cu-hNFs and RT@Zn-hNFs exhibited IC₅₀ values of 1977 ± 357&#xa0;µg/mL and 1511 ± 392&#xa0;µg/mL, respectively, confirming their low cytotoxicity toward A549 cells. Among the tested bacterial strains, RT@Cu-hNFs demonstrated stronger antibacterial activity than RT@Zn-hNFs, particularly against <i>Staphylococcus aureus</i>. Overall, the findings highlight the promising multifunctional potential of <i>R. tataricum</i>-derived nanoflowers for antioxidant, enzyme-inhibitory, and antimicrobial applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Green Fabrication of Copper and Zinc Nanoflowers Using Rheum tataricum L. and Evaluation of their Antioxidant, Enzyme-Inhibitory, Antimicrobial, and Anticancer Properties

  • 期刊论文

  • 发表日期：

    2025年12月10日

查看全文
  • Metin Yıldırım,
  • Burcu Somtürk Yilmaz,
  • Mehmet Çimentepe,
  • Adem Necip,
  • Özden Dellal

摘要

In this study, Zn- and Cu-based nanoflowers were synthesized using Rheum tataricum L. root extract through a green and eco-friendly approach. The nanostructures were preliminarily characterized using SEM, FTIR, XRD, and EDX analyses. Subsequently, their biological activities were comprehensively evaluated, including antioxidant potential (DPPH and ABTS assays), acetylcholinesterase (AChE) inhibitory properties, cytotoxic effects on A549 lung cancer cells, and antimicrobial as well as antibiofilm activities against clinically relevant pathogenic bacteria with different resistance profiles. RT@Cu-hNFs exhibited IC₅₀ values of 221 µg/mL (DPPH) and 146 µg/mL (ABTS), whereas RT@Zn-hNFs showed stronger antioxidant activity with IC₅₀ values of 62.7 µg/mL and 4.7 µg/mL, respectively. The AChE inhibitory IC₅₀ values were 53 µg/mL for RT@Cu-hNFs and 29.6 µg/mL for RT@Zn-hNFs, indicating a higher enzyme inhibitory potential for the Zn-based nanoflowers. Cytotoxicity assays revealed that RT@Cu-hNFs and RT@Zn-hNFs exhibited IC₅₀ values of 1977 ± 357 µg/mL and 1511 ± 392 µg/mL, respectively, confirming their low cytotoxicity toward A549 cells. Among the tested bacterial strains, RT@Cu-hNFs demonstrated stronger antibacterial activity than RT@Zn-hNFs, particularly against Staphylococcus aureus. Overall, the findings highlight the promising multifunctional potential of R. tataricum-derived nanoflowers for antioxidant, enzyme-inhibitory, and antimicrobial applications.