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<p>A Cu(II)–Schiff base complex was examined through electrochemical, spectroscopic, and biological methods. Cyclic voltammetry in KCl solution showed concentration- and scan rate-dependent redox behavior, from which diffusion coefficients, stability constants, and Gibbs free energies were derived. Reduced current intensity and potential shifts upon ligand addition confirmed stable, spontaneous Cu–ligand complexation. The DPPH assay revealed strong antioxidant activity (IC₅₀ = 0.0704&#xa0;mg/mL), comparable to standard antioxidants. Molecular docking with the MIA protein (PDB: 5IXB) showed favorable H-bonding and π–cation interactions, indicating biomedical potential. UV–vis titration with calf thymus DNA produced hypochromic and a slight redshift, suggesting intercalative binding with K<sub>b</sub> ≈ 10⁴–10⁵ M⁻¹. Overall, the Cu–Schiff base complex exhibits redox activity, antioxidant capacity, and DNA affinity suitable for biosensing or therapeutic applications.</p>

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Analytical and Molecular Insights into the Cu(II)–Schiff Base System: Electrochemical Redox Behavior, Thermodynamic Evaluation, and DNA Affinity

  • 期刊论文

  • 发表日期：

    2025年12月15日

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  • Elsayed M. AbouElleef,
  • M.A. Diab,
  • A.Z. El-Sonbati,
  • R.R. Atta,
  • H.H. Hassanin,
  • Sh.M. Morgan

摘要

A Cu(II)–Schiff base complex was examined through electrochemical, spectroscopic, and biological methods. Cyclic voltammetry in KCl solution showed concentration- and scan rate-dependent redox behavior, from which diffusion coefficients, stability constants, and Gibbs free energies were derived. Reduced current intensity and potential shifts upon ligand addition confirmed stable, spontaneous Cu–ligand complexation. The DPPH assay revealed strong antioxidant activity (IC₅₀ = 0.0704 mg/mL), comparable to standard antioxidants. Molecular docking with the MIA protein (PDB: 5IXB) showed favorable H-bonding and π–cation interactions, indicating biomedical potential. UV–vis titration with calf thymus DNA produced hypochromic and a slight redshift, suggesting intercalative binding with Kb ≈ 10⁴–10⁵ M⁻¹. Overall, the Cu–Schiff base complex exhibits redox activity, antioxidant capacity, and DNA affinity suitable for biosensing or therapeutic applications.