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<p>An integral component of centromeric proteins, centromere protein I (CENPI) plays a pivotal role in chromosomal segregation and alignment. Nonetheless, there has been little investigation on its link to oral squamous cell carcinoma (OSCC).This study demonstrated that CENPI was significantly upregulated in OSCC tissues and cell lines compared to normal controls. Functional assays revealed that CENPI silencing suppressed OSCC cell proliferation, colony formation, migration, and invasion, and induced G1 phase cell cycle arrest. Consistently, CENPI knockdown inhibited tumor growth in a xenograft mouse model. Mechanistically, CENPI was found to directly bind to the E2F4 promoter and enhance its transcription. Crucially, the tumor-suppressive effects of CENPI knockdown were effectively rescued by E2F4 overexpression. In conclusion, the CENPI-E2F4 axis plays a critical oncogenic role in OSCC progression, presenting a promising novel therapeutic target for this malignancy.</p>

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CENPI Promotes the Progression in Oral Squamous Cell Carcinoma and Is Regulated by E2F4

  • 期刊论文

  • 发表日期：

    2025年11月22日

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  • Yi Chen,
  • Fei Duan,
  • Xinxing Duan,
  • Xutao Wen,
  • Xiong Yu,
  • Dan Li

摘要

An integral component of centromeric proteins, centromere protein I (CENPI) plays a pivotal role in chromosomal segregation and alignment. Nonetheless, there has been little investigation on its link to oral squamous cell carcinoma (OSCC).This study demonstrated that CENPI was significantly upregulated in OSCC tissues and cell lines compared to normal controls. Functional assays revealed that CENPI silencing suppressed OSCC cell proliferation, colony formation, migration, and invasion, and induced G1 phase cell cycle arrest. Consistently, CENPI knockdown inhibited tumor growth in a xenograft mouse model. Mechanistically, CENPI was found to directly bind to the E2F4 promoter and enhance its transcription. Crucially, the tumor-suppressive effects of CENPI knockdown were effectively rescued by E2F4 overexpression. In conclusion, the CENPI-E2F4 axis plays a critical oncogenic role in OSCC progression, presenting a promising novel therapeutic target for this malignancy.