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<p>The purpose of this study is to evaluate the efficacy of copper carbonate (CuCO<sub>3</sub>) nanoparticles in promoting wound healing in diabetic and non-diabetic mice. Diabetes mellitus is a prevalent and serious condition characterized by elevated blood glucose levels due to insufficient insulin production or the body’s impaired response to insulin. This condition frequently leads to complications such as diabetic wounds, which are difficult to heal due to poor circulation and neuropathy, posing significant challenges in patient care. Standardized wounds were created on the dorsal area of mice, divided into four groups (Non-Diabetic Control, Non-Diabetic CuCO<sub>3</sub>-treated, Diabetic Control, and Diabetic CuCO<sub>3</sub>-treated), and wound areas were measured over 14 days. Mice treated with CuCO<sub>3</sub> nanoparticles exhibited faster wound healing compared to their respective control groups, regardless of diabetic status. Molecular docking revealed that CuCO<sub>3</sub> showed favorable negative docking scores with selected receptor proteins such as VEGF (-6.946 kcal/mol), TGF-β (-5.314 kcal/mol), FGF (-4.926 kcal/mol), MMP9 (-4.355 kcal/mol), HIF-1α (-4.811 kcal/mol), and PKC-β II (-5.370 kcal/mol). It shows the best binding affinity with VEGF that promotes angiogenesis to the wound site. These findings with in-silico computational modeling demonstrate the potential of CuCO<sub>3</sub> nanoparticles to enhance wound healing in both diabetic and non-diabetic conditions, highlighting their promise in developing effective therapies for diabetic wound management.</p>

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Investigating the Wound Healing Potential of CuCO3 Nanoparticles in Alloxan-Induced Diabetic Albino Mice: An Experimental and In Silico Approach

  • 期刊论文

  • 发表日期：

    2025年12月26日

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  • Muhammad Saqib Rafiq,
  • Jabbir Ali Khan,
  • Ashfaq Ahmad Shah Bukhari,
  • Samra Shafqat,
  • Ahmad Waheed,
  • Muhammad Yasir Abbas,
  • Muhammad Waseem Aslam,
  • Imran Ibrahim Shaikh,
  • Khalid S. Almaary,
  • Muhammad Saleem Khan

摘要

The purpose of this study is to evaluate the efficacy of copper carbonate (CuCO3) nanoparticles in promoting wound healing in diabetic and non-diabetic mice. Diabetes mellitus is a prevalent and serious condition characterized by elevated blood glucose levels due to insufficient insulin production or the body’s impaired response to insulin. This condition frequently leads to complications such as diabetic wounds, which are difficult to heal due to poor circulation and neuropathy, posing significant challenges in patient care. Standardized wounds were created on the dorsal area of mice, divided into four groups (Non-Diabetic Control, Non-Diabetic CuCO3-treated, Diabetic Control, and Diabetic CuCO3-treated), and wound areas were measured over 14 days. Mice treated with CuCO3 nanoparticles exhibited faster wound healing compared to their respective control groups, regardless of diabetic status. Molecular docking revealed that CuCO3 showed favorable negative docking scores with selected receptor proteins such as VEGF (-6.946 kcal/mol), TGF-β (-5.314 kcal/mol), FGF (-4.926 kcal/mol), MMP9 (-4.355 kcal/mol), HIF-1α (-4.811 kcal/mol), and PKC-β II (-5.370 kcal/mol). It shows the best binding affinity with VEGF that promotes angiogenesis to the wound site. These findings with in-silico computational modeling demonstrate the potential of CuCO3 nanoparticles to enhance wound healing in both diabetic and non-diabetic conditions, highlighting their promise in developing effective therapies for diabetic wound management.