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<p>The major objective of the current study is to investigate the&#xa0;protective and therapeutic potential of <i>Bacopa monnieri</i> extract and synthetic antioxidants (N-acetyl cysteine, ascorbic&#xa0;acid, tocopheryl&#xa0;acetate,&#xa0;and thiamine&#xa0;mixture) against lead-induced hematological toxicity in Swiss albino mice. HPLC analysis of the&#xa0;ethanolic extract of <i>Bacopa monnieri</i> (<i>B. monnieri</i>) revealed a rich profile of bioactive compounds, including flavonoids like apigenin and luteolin, bacosides, and bacopasaponins. In vivo experiments demonstrated dose-dependent statistically significant (<i>p</i> &lt; 0.001) hematological alterations in lead-exposed groups, showing reductions in hemoglobin (Hb), red blood cell (RBC) count, platelet count, hematocrit, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH), alongside an increase in white blood cell (WBC) count as compared to the&#xa0;control, indicating severe hematotoxic effects of lead. In synergistic study groups, co-administration of lead acetate&#xa0;with synthetic antioxidants or <i>B. monnieri</i> extract conferred protection against lead-induced toxicity by mitigating alterations in hematological parameters of Hb, RBC, WBC,&#xa0;and platelet count, with a&#xa0;more pronounced effect of <i>B. monnieri</i> than synthetic antioxidants. Curative study groups further demonstrated restoration of hematological parameters near the&#xa0;control group baseline, highlighting the superior efficacy of <i>B. monnieri</i> in reversing lead-induced toxicity. In conclusion, the findings of the study imply that the herbal antioxidant <i>B. monnieri</i> has better potential to be an effective ameliorative therapeutic agent against lead-induced hematological toxicity as compared to synthetic antioxidants,&#xa0;which may be attributed to the&#xa0;presence of plentiful phytochemicals in its extract that can be employed effectively for the development of plant-based therapies for the eradication of lead poisoning in endemic regions.</p>

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Efficacy of Bacopa monnieri in Mitigating Lead-Induced Blood Toxicity in Swiss Albino Mice Compared to Synthetic Antioxidants

  • 期刊论文

  • 发表日期：

    2025年11月6日

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  • Flora Shah,
  • Nayan Jain,
  • Vennmathi Muthu,
  • Sakthivel Muthu,
  • Jamith Basha Abdul Wahid,
  • Mumtaj Shah,
  • Karuppiah Nagaraj

摘要

The major objective of the current study is to investigate the protective and therapeutic potential of Bacopa monnieri extract and synthetic antioxidants (N-acetyl cysteine, ascorbic acid, tocopheryl acetate, and thiamine mixture) against lead-induced hematological toxicity in Swiss albino mice. HPLC analysis of the ethanolic extract of Bacopa monnieri (B. monnieri) revealed a rich profile of bioactive compounds, including flavonoids like apigenin and luteolin, bacosides, and bacopasaponins. In vivo experiments demonstrated dose-dependent statistically significant (p < 0.001) hematological alterations in lead-exposed groups, showing reductions in hemoglobin (Hb), red blood cell (RBC) count, platelet count, hematocrit, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH), alongside an increase in white blood cell (WBC) count as compared to the control, indicating severe hematotoxic effects of lead. In synergistic study groups, co-administration of lead acetate with synthetic antioxidants or B. monnieri extract conferred protection against lead-induced toxicity by mitigating alterations in hematological parameters of Hb, RBC, WBC, and platelet count, with a more pronounced effect of B. monnieri than synthetic antioxidants. Curative study groups further demonstrated restoration of hematological parameters near the control group baseline, highlighting the superior efficacy of B. monnieri in reversing lead-induced toxicity. In conclusion, the findings of the study imply that the herbal antioxidant B. monnieri has better potential to be an effective ameliorative therapeutic agent against lead-induced hematological toxicity as compared to synthetic antioxidants, which may be attributed to the presence of plentiful phytochemicals in its extract that can be employed effectively for the development of plant-based therapies for the eradication of lead poisoning in endemic regions.