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<p>Green nanotechnology can provide new avenues for drug and insecticide discovery. This study aimed at synthesizing and evaluating the potential of silver nanoparticles, using an innovative plant-driven synthesis approach, with the potential to be used as an endectocide. Optimized silver nanoparticles using <i>Ceiba pentandra</i> (CP–AgNPs) were evaluated for their hemotoxic and killing activities against the deadliest malaria parasite <i>Plasmodium falciparum</i> (<i>Pf</i>) and three mosquito species (<i>Culex quinquefasciatus</i>,<i> Anopheles stephensi</i>, and <i>Aedes aegypti</i>) of medical importance. Optimized CP–AgNPs were predominantly spheroidal, stable, polycrystalline, and coated with several phytochemical compounds, including terpenoids, alkaloids, and phenols. CP–AgNPs exhibited good hemocompatibility and high lethal activity on <i>Pf</i> 3D7 and RKL9 strains, with respective IC<sub>50</sub> values of 9.71&#xa0;µg/mL and 15.57&#xa0;µg/mL. Likewise, LC<sub>50</sub> values were &lt; 20&#xa0;µg/mL in the three mosquito species after 24-h exposure, and the CP–AgNPs were most toxic against <i>An. stephensi</i> (LC<sub>50</sub> = 13.48&#xa0;µg/mL). Green AgNPs could be an interesting tool for discovering and developing eco-friendly and effective antimalarial drugs and insecticides.</p>

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Bio-inspired Synthesis, Characterization, and Biomedical Applications of Optimized Ceiba pentandra Silver Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年5月16日

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  • Loick Pradel Kojom Foko,
  • Joseph Hawadak,
  • Philippe Belle Ebanda Kedi,
  • Veena Pande,
  • Vineeta Singh

摘要

Green nanotechnology can provide new avenues for drug and insecticide discovery. This study aimed at synthesizing and evaluating the potential of silver nanoparticles, using an innovative plant-driven synthesis approach, with the potential to be used as an endectocide. Optimized silver nanoparticles using Ceiba pentandra (CP–AgNPs) were evaluated for their hemotoxic and killing activities against the deadliest malaria parasite Plasmodium falciparum (Pf) and three mosquito species (Culex quinquefasciatus, Anopheles stephensi, and Aedes aegypti) of medical importance. Optimized CP–AgNPs were predominantly spheroidal, stable, polycrystalline, and coated with several phytochemical compounds, including terpenoids, alkaloids, and phenols. CP–AgNPs exhibited good hemocompatibility and high lethal activity on Pf 3D7 and RKL9 strains, with respective IC50 values of 9.71 µg/mL and 15.57 µg/mL. Likewise, LC50 values were < 20 µg/mL in the three mosquito species after 24-h exposure, and the CP–AgNPs were most toxic against An. stephensi (LC50 = 13.48 µg/mL). Green AgNPs could be an interesting tool for discovering and developing eco-friendly and effective antimalarial drugs and insecticides.