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<p>This study investigated the association and mediating mechanisms between magnesium depletion score (MDS) and kidney stones (KDS) in gout patients through a cross-sectional analysis. Logistic regression analysis of 502 gout patients revealed a significant positive association between MDS grade and KDS (OR = 2.14, 95% CI: 1.78–2.58), with the risk remaining elevated in the MDS4 group after adjusting for confounders (OR = 6.25, 95% CI: 2.38–16.44).Causal mediation analysis indicated that MDS fully explained the effect of serum uric acid (SUA) on KDS, suggesting that disrupted magnesium metabolism plays a key role in gout-related kidney injury. Subgroup analysis revealed an increased risk of KDS in obese, hypertensive, and diabetic patients with MDS. MDS should be incorporated into clinical risk assessments for gout, and magnesium supplementation or combined uric acid-lowering therapy should be recommended for high-risk groups to prevent KDS.</p>

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The Relationship Between Magnesium Depletion Score and Kidney Stone Risk in Gout Patients: a Mediation Analysis

  • 期刊论文

  • 发表日期：

    2025年4月23日

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  • Jing Liu,
  • Yu Lei

摘要

This study investigated the association and mediating mechanisms between magnesium depletion score (MDS) and kidney stones (KDS) in gout patients through a cross-sectional analysis. Logistic regression analysis of 502 gout patients revealed a significant positive association between MDS grade and KDS (OR = 2.14, 95% CI: 1.78–2.58), with the risk remaining elevated in the MDS4 group after adjusting for confounders (OR = 6.25, 95% CI: 2.38–16.44).Causal mediation analysis indicated that MDS fully explained the effect of serum uric acid (SUA) on KDS, suggesting that disrupted magnesium metabolism plays a key role in gout-related kidney injury. Subgroup analysis revealed an increased risk of KDS in obese, hypertensive, and diabetic patients with MDS. MDS should be incorporated into clinical risk assessments for gout, and magnesium supplementation or combined uric acid-lowering therapy should be recommended for high-risk groups to prevent KDS.