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<p>Infertility is a multifaceted and pressing global health challenge, with male reproductive impairment playing a significant role in its overall burden. Zinc (Zn), a biologically indispensable trace element, is fundamental to spermatogenesis and overall male reproductive function. This narrative review explores the following aspects: (1) the mechanistic function of Zn in spermatogenesis, (2) the impact of oxidative stress on Zn status and male infertility, (3) the interplay between Zn and lipid metabolism in male reproductive physiology, (4) the relationship between Zn concentrations and semen parameters, and (5) the effects of Zn supplementation on sperm quality, alongside relevant institutional recommendations. The molecular pathways underlying Zn deficiency-induced enzymatic dysfunction, oxidative stress, and lipid homeostasis disruption remain partially elucidated, warranting further investigation into their interdependent effects on male infertility. While accumulating evidence suggests that Zn supplementation may have therapeutic potential in male infertility management, guidelines for its clinical application vary considerably across institutions and regions. To establish a clear and evidence-based framework for the function of Zn in male reproductive health, future research should prioritize determining of optimal Zn levels, the mechanistic links between Zn and lipid metabolism, and the long-term clinical outcomes of Zn supplementation in infertile populations.</p>

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Zinc as a Modulator of Male Fertility: Interplay Between Lipid Metabolism, Oxidative Stress, and Sperm Function

  • 期刊论文

  • 发表日期：

    2025年4月16日

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  • Aleksandra Veselinović,
  • Milica Zeković,
  • Marija Paunović,
  • Marija Šorak,
  • Danijela Ristić-Medić,
  • Vesna Vučić

摘要

Infertility is a multifaceted and pressing global health challenge, with male reproductive impairment playing a significant role in its overall burden. Zinc (Zn), a biologically indispensable trace element, is fundamental to spermatogenesis and overall male reproductive function. This narrative review explores the following aspects: (1) the mechanistic function of Zn in spermatogenesis, (2) the impact of oxidative stress on Zn status and male infertility, (3) the interplay between Zn and lipid metabolism in male reproductive physiology, (4) the relationship between Zn concentrations and semen parameters, and (5) the effects of Zn supplementation on sperm quality, alongside relevant institutional recommendations. The molecular pathways underlying Zn deficiency-induced enzymatic dysfunction, oxidative stress, and lipid homeostasis disruption remain partially elucidated, warranting further investigation into their interdependent effects on male infertility. While accumulating evidence suggests that Zn supplementation may have therapeutic potential in male infertility management, guidelines for its clinical application vary considerably across institutions and regions. To establish a clear and evidence-based framework for the function of Zn in male reproductive health, future research should prioritize determining of optimal Zn levels, the mechanistic links between Zn and lipid metabolism, and the long-term clinical outcomes of Zn supplementation in infertile populations.