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<p>Chitosan (CTS) is widely recognized for its intrinsic antimicrobial properties. Recent advancements demonstrate that the antimicrobial efficacy of CTS can be significantly enhanced through complexation with various metals such as Cu(II), Zn(II), Ag(I), Co(II), Ni(II), and many other metals. This chelation not only improves the physicochemical stability and solubility of the complexes but also promotes synergistic antimicrobial effects by facilitating controlled release of bioactive metal ions. These metal ions exert bactericidal effects through mechanisms such as generation of reactive oxygen species (ROS), enzyme inactivation, and disruption of microbial metabolism. Consequently, CTS-metal complexes demonstrate superior antibacterial activity compared to pristine CTS or metal ions alone. This review aims to provide a comprehensive overview of CTS-metal complexes focusing on their antimicrobial potential and enhanced activity upon complexation. Understanding the relationship between CTS and metal ions offers valuable insights into designing potent antimicrobial agents that can effectively address the growing challenge of AMR.</p>

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Enhancing Antimicrobial Efficacy: The Role of Metal Complexation in Chitosan-Based Antimicrobial Agents

  • 期刊论文

  • 发表日期：

    2026年6月29日

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  • Muhanad Alhujaily,
  • Alaa Shafie,
  • Mohammed Sanad Alhussaini,
  • AbdulRahman Abdulla Ibrahim Alyahya

摘要

Chitosan (CTS) is widely recognized for its intrinsic antimicrobial properties. Recent advancements demonstrate that the antimicrobial efficacy of CTS can be significantly enhanced through complexation with various metals such as Cu(II), Zn(II), Ag(I), Co(II), Ni(II), and many other metals. This chelation not only improves the physicochemical stability and solubility of the complexes but also promotes synergistic antimicrobial effects by facilitating controlled release of bioactive metal ions. These metal ions exert bactericidal effects through mechanisms such as generation of reactive oxygen species (ROS), enzyme inactivation, and disruption of microbial metabolism. Consequently, CTS-metal complexes demonstrate superior antibacterial activity compared to pristine CTS or metal ions alone. This review aims to provide a comprehensive overview of CTS-metal complexes focusing on their antimicrobial potential and enhanced activity upon complexation. Understanding the relationship between CTS and metal ions offers valuable insights into designing potent antimicrobial agents that can effectively address the growing challenge of AMR.