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<p>Articular inflammatory processes are common in rheumatoid arthritis, osteoarthritis, and psoriatic arthritis. Standard therapy relies on oral anti-inflammatory drugs, which can cause systemic side effects with prolonged use. This has driven the search for natural alternatives and safer drug delivery systems. Intra-articular hydrogels enriched with bioactive compounds represent a promising approach, providing localized release of therapeutic molecules and reducing adverse effects. This study developed and characterized alginate (ALG)-based hydrogels enriched with bioactive compounds from the marine sponge <i>Dysidea robusta</i> and evaluated their anti-inflammatory potential in vitro. Hydrogels were prepared by dissolving ALG (1.5% and 3% w/v) and cross-linking with CaCO₃. Characterization included mass stability, scanning electron microscopy (SEM), and oscillatory rheology. Biological assays on fibroblasts and chondrocytes measured cytokine expression (IL-6 and TNF-α) by enzyme-linked immunosorbent assay (ELISA). The hydrogels showed initial mass gain followed by controlled degradation and a lamellar porous structure. Rheological analysis revealed tunable gelation and elasticity, while in vitro assays confirmed biocompatibility and a significant reduction of inflammatory markers. These findings indicate that ALG-based hydrogels containing <i>D. robusta</i> bioactives combine desirable physicochemical properties with anti-inflammatory activity, making them promising candidates for targeted drug delivery and tissue engineering.</p>

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Analysis of the Anti-inflammatory Effects of a Delivery System Based on Alginate Hydrogels Enriched with Bioactive Compounds from Marine Sponge Dysidea robusta

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月6日

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  • Homero Garcia-Motta,
  • Cintia Cristina Santi Martignago,
  • Mirian Bonifacio,
  • Dalete Christine da Silva Souza,
  • Lais Caroline Souza-Silva,
  • Beatriz Soares-Silva,
  • Anabella Patricia Rosso,
  • Isabelly Bertochi Veroneze,
  • Marcelo Assis,
  • Fernando Carlos Giacomelli,
  • Sandra Andrea Cruz,
  • João Henrique Ghilardi Lago,
  • Renata Granito,
  • Lívia Assis,
  • Alessandra Mussi Ribeiro,
  • Ana Claudia Muniz Rennó

摘要

Articular inflammatory processes are common in rheumatoid arthritis, osteoarthritis, and psoriatic arthritis. Standard therapy relies on oral anti-inflammatory drugs, which can cause systemic side effects with prolonged use. This has driven the search for natural alternatives and safer drug delivery systems. Intra-articular hydrogels enriched with bioactive compounds represent a promising approach, providing localized release of therapeutic molecules and reducing adverse effects. This study developed and characterized alginate (ALG)-based hydrogels enriched with bioactive compounds from the marine sponge Dysidea robusta and evaluated their anti-inflammatory potential in vitro. Hydrogels were prepared by dissolving ALG (1.5% and 3% w/v) and cross-linking with CaCO₃. Characterization included mass stability, scanning electron microscopy (SEM), and oscillatory rheology. Biological assays on fibroblasts and chondrocytes measured cytokine expression (IL-6 and TNF-α) by enzyme-linked immunosorbent assay (ELISA). The hydrogels showed initial mass gain followed by controlled degradation and a lamellar porous structure. Rheological analysis revealed tunable gelation and elasticity, while in vitro assays confirmed biocompatibility and a significant reduction of inflammatory markers. These findings indicate that ALG-based hydrogels containing D. robusta bioactives combine desirable physicochemical properties with anti-inflammatory activity, making them promising candidates for targeted drug delivery and tissue engineering.