Scholarlink

<p>Squalene epoxidase (SE) is located in the microsomes of the endoplasmic reticulum and acts as a biocatalyst in the biological process where squalene is converted into 2,3-oxidosqualene (MOS). As a precursor for the biosynthesis pathways of important secondary metabolites such as triterpenes, the catalytic efficiency of SE influences the biosynthetic efficiency of these triterpenes by affecting the synthesis of MOS. Therefore, SE is considered a key biological component in the triterpene biosynthesis pathway, and SE from various organisms has been widely studied. By summarizing the bioinformatics analysis, crystal structure, mechanism of action, gene function analysis, and mechanisms in human diseases related to squalene epoxidase, this review provides insights for future research on SE and its associated metabolic products.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Squalene Epoxidase: A Key Enzymatic Component in the Triterpenoid Biosynthesis Pathway

  • 期刊论文

  • 发表日期：

    2026年1月9日

查看全文
  • Di Liu,
  • Xiaofan Yu,
  • Sanyu Qin,
  • Tingting Zheng,
  • Xintong Bao,
  • Xinqin Li

摘要

Squalene epoxidase (SE) is located in the microsomes of the endoplasmic reticulum and acts as a biocatalyst in the biological process where squalene is converted into 2,3-oxidosqualene (MOS). As a precursor for the biosynthesis pathways of important secondary metabolites such as triterpenes, the catalytic efficiency of SE influences the biosynthetic efficiency of these triterpenes by affecting the synthesis of MOS. Therefore, SE is considered a key biological component in the triterpene biosynthesis pathway, and SE from various organisms has been widely studied. By summarizing the bioinformatics analysis, crystal structure, mechanism of action, gene function analysis, and mechanisms in human diseases related to squalene epoxidase, this review provides insights for future research on SE and its associated metabolic products.